Results 221 to 230 of about 107,453 (245)

Contribution of RNA-RNA Interactions Mediated by the Genome Packaging Signals for the Selective Genome Packaging of Influenza A Virus

Journal of Virology, 2022
While numerous viral genomes comprise a single genome segment, the influenza A virus possesses eight segmented genomes. Influenza A virus can benefit from having a segmented genome because the segments can reassort with other strains of the influenza virus to create new genetically distinct strains.
Sho Miyamoto, Yukiko Muramoto, Keiko Shindo, Yoko Fujita-Fujiharu, Takeshi Morikawa, Ryoma Tamura, Jamie L. Gilmore, Masahiro Nakano, Takeshi Noda   +8 more
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Packaging of HCV-RNA into lentiviral vector

Biochemical and Biophysical Research Communications, 2011
The advent of infectious molecular clones of Hepatitis C virus (HCV) has unlocked the understanding of HCV life cycle. However, packaging of the genomic RNA, which is crucial to generate infectious viral particles, remains poorly understood. Molecular interactions of the domain 1 (D1) of HCV Core protein and HCV RNA have been described in vitro.
Vincent, Caval, Eric, Piver, Roland, Ivanyi-Nagy, Jean-Luc, Darlix, Jean-Christophe, Pagès   +4 more
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Packaging of heterologous RNAs by a minimal bovine leukemia virus RNA packaging signal into virus particles

Archives of Virology, 2005
A minimal bovine leukemia virus (BLV) RNA packaging sequence (E) required for heterologous RNAs to be packaged into BLV particles was analyzed. The BLV E was inserted into a non-viral vector, pLacZ, in order to determine if packaging of the non-viral vector RNA would occur. The construct was transfected into cells chronically infected with BLV in order
N A, Jewell, L M, Mansky
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Revolution in an RNA-packaging capsid

Science, 2021
Directed Evolution Artificial nucleocapsid proteins, which could be analogous to those used by viruses to package their genomes, are a promising way to protect and deliver RNAs. Using an escalating challenge by nucleases, Tetter et al. evolved a protein that forms multimeric, spherical cages into a highly efficient capsid that selectively packages its ...
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HIV‐1 RNA Packaging

2007
Publisher Summary This chapter focuses on the concept of human immunodeficiency virus type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process by which the virus negotiates the trafficking of a minority species of mRNA through a particular cellular pathway to become its genome.
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Packaged Heteroclite Subgenomic RNAs of PRRSV

2001
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of the Arteriviridae family of the Nidovirales (Meulenberg et al, 1993b; Nelsen et al., 1999). While the complete genomes of three PRRSV strains are known (Allende et al., 1999; Meulenberg et al., 1993; Nelsen et al., 1999), main questions remains to be elucidated concerning viral ...
S, Yuan, M P, Murtaugh, K S, Faaberg
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Retroviral RNA packaging: a review

1994
In retroviruses, the "Gag" or core polyprotein is capable of assembling into virus particles and packaging the genomic RNA of the virus. How this protein recognizes viral RNA is not understood. Gag polyproteins contain a zinc-finger domain; mutants with changes in this domain assemble into virions, but a large fraction of these particles lack viral RNA.
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Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging

Journal of Virology, 1975
Extracellular maturation of Bratislava 77(B77) sarcoma virus RNA involves a stabilization of linkage between 35S subunits since the Tm of 60 to 70S RNA in the presence of 0.5 M NaCl increases from 56 to 67.5 C as the age of the virus increases. This stabilization process is strongly temperature dependent; the rate at 45 C is increased fourfold over the
C M, Stoltzfus, P N, Snyder
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Sequences Required for Replication and Packaging of IBV RNA

2001
We have used a naturally occurring IBV defective RNA (D-RNA), CD-91 (9.1 kb; Penzes et al., 1994) to investigate IBV replication and packaging signals. This D-RNA comprised the 5’-most 1133 nucleotides (domain I, including the 528 nucleotide 5’ untranslated region, UTR) and 3’-most 1626 nucleotides (domain III) of the genome and a middle section ...
K, Dalton, R, Casais, K, Shaw, K, Stirrups, S, Evans, T D, Brown, P, Britton, D, Cavanagh   +7 more
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Retroviral RNA Packaging: Sequence Requirements and Implications

1990
Unlike many animal viruses, infection by retroviruses generally does not lead to cessation of host RNA synthesis. Despite the high levels of host RNA in infected cells, the vast majority of retroviral particles contain a precise genomic complex consisting of two molecules of genomic RNA, rather than cellular or subgenomic viral mRNAs.
M L, Linial, A D, Miller
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