Results 31 to 40 of about 2,625,316 (382)
Nucleic Acids Research, 1983 We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters.
J. Dignam, R. Lebovitz, R. Roeder
semanticscholar +1 more source
Activation of σ28-dependent transcription inEscherichia coliby the cyclic AMP receptor protein requires an unusual promoter organization [PDF]
, 2010 The Escherichia coli aer regulatory region contains a single promoter that is recognized by RNA polymerase containing the flagellar sigma factor, σ28.
Busby, Stephen J. W. +3 more
core +2 more sources
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Science, 2020 A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin +24 more
semanticscholar +1 more source
Nature Communications, 2020 The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon +12 more
semanticscholar +1 more source
Current Opinion in Structural Biology, 2009 The recently solved X-ray crystal structures of archaeal RNA polymerase (RNAP) allow a structural comparison of the transcription machinery among all three domains of life. Archaeal transcription is very simple and all components, including the structures of general transcription factors and RNAP, are highly conserved in eukaryotes. Therefore, it could
Akira Hirata, Katsuhiko S. Murakami
openaire +3 more sources
Mathematical Biosciences and Engineering, 2019 In the classical chemostat, the output of the system has no effect on its input. This contrasts with many ecological systems, where the output at the end of a growing season affects nutrient inputs for subsequent seasons.
Irakli Loladze
doaj +1 more source
A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei [PDF]
, 1975 DNA-dependent RNA polymerases (EC 2.7.7.6) were extracted and partially purified form the nuclei of rat ascites hepatoma cells (AH-130) induced by 4-dimethylaminoazobenzene.
Misumi, Hiromasa
core +1 more source
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery
SLAS Discovery, 2020 COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019.
Wei Zhu +5 more
semanticscholar +1 more source
Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
doaj +1 more source
Nucleolar RNA polymerase II drives ribosome biogenesis
Nature, 2020 Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli 1 , 2 .
K. Abraham +24 more
semanticscholar +1 more source