Results 31 to 40 of about 2,226,379 (341)
Journal of Biological Chemistry, 2020 Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2).
Calvin J. Gordon +4 more
semanticscholar +1 more source
Contractions of the C-Terminal Domain of Saccharomyces cerevisiae Rpb1p Are Mediated by Rad5p
G3: Genes, Genomes, Genetics, 2020 The C-terminal domain (CTD) is an essential domain of the largest subunit of RNA polymerase II, Rpb1p, and is composed of 26 tandem repeats of a seven-amino acid sequence, YSPTSPS.
Taylor Stewart +3 more
doaj +1 more source
Gene Transcription as a Limiting Factor in Protein Production and Cell Growth
G3: Genes, Genomes, Genetics, 2020 Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz +3 more
doaj +1 more source
RNA Biology, 2022 Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms ...
Simon Jeanneau +2 more
doaj +1 more source
Nucleic Acids Research, 1983 We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters.
J. Dignam, R. Lebovitz, R. Roeder
semanticscholar +1 more source
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens
Microbial Cell, 2022 Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems.
Xinyun Cao +2 more
doaj +1 more source
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Science, 2020 A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin +24 more
semanticscholar +1 more source
Nature Communications, 2020 The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon +12 more
semanticscholar +1 more source
Current Opinion in Structural Biology, 2009 The recently solved X-ray crystal structures of archaeal RNA polymerase (RNAP) allow a structural comparison of the transcription machinery among all three domains of life. Archaeal transcription is very simple and all components, including the structures of general transcription factors and RNAP, are highly conserved in eukaryotes. Therefore, it could
Akira Hirata, Katsuhiko S. Murakami
openaire +3 more sources
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
doaj +1 more source