Results 201 to 210 of about 503,680 (311)

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Nelfb promotes dermal white adipose tissue formation through RNA polymerase II-mediated adipogenic gene regulation. [PDF]

Development
Mahapatra S, Gomez J, Batzorig U, Liu Y, Fernández-Méndez C, Chen Y, Sen GL.   +6 more
europepmc   +1 more source

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II

Molecular and Cellular Biology, 2003
N. Krogan, Minkyu Kim, A. Tong, A. Golshani, G. Cagney, Veronica Canadien, D. Richards, B. Beattie, A. Emili, Charles Boone, A. Shilatifard, S. Buratowski, J. Greenblatt   +12 more
semanticscholar   +1 more source

Advances in MoS2‐Au Nanostructured Platforms for Cancer‐Derived miRNA Detection

Advanced Materials Interfaces, EarlyView.
This figure presents the roadmap and scope of this review on microRNA detection technologies, with emphasis on MoS2 and MoS2–Au hybrid nanostructures. It traces the evolution from conventional assays to MoS2‐based SERS platforms, highlights synthesis, interfacial chemistry, and signal‐enhancement mechanisms, and summarizes key challenges and future ...
Faith Mokobi Zablon, Kristen Dellinger, Shyam Aravamudhan   +2 more
wiley   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Direct recruitment of RNA Polymerase II by NANOG to activated target genes

Mullin NP, Barbieri E, Zhang J, Vojtek M, McGarvey A, Colby D, Tomlinson S, Chambers IP.   +7 more
europepmc   +1 more source

Multi-omics analysis reveals RNA polymerase II degradation as a novel mechanism of PF-3758309's anti-tumor activity. [PDF]

Cell Death Discov
Jia X, Zhang J, Pan L, He J, Zhu M, Zhao L, Zhang X, Zhao W, Xie D, Shen X, Liu B, Tan M.   +11 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.

Cell, 2016
Laura Baranello, Damian Wójtowicz, Kairong Cui, B. N. Devaiah, Hye‐Jung Chung, Ka Yim Chan-Salis, R. Guha, Kelli M. Wilson, Xiaohu Zhang, Hongliang Zhang, J. Piotrowski, Craig J. Thomas, D. Singer, B. Pugh, Y. Pommier, T. Przytycka, Fedor Kouzine, B. Lewis, K. Zhao, David Levens   +19 more
semanticscholar   +1 more source