Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao +3 more
wiley +1 more source
Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. [PDF]
Naganuma M +11 more
europepmc +1 more source
This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and antiinflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai +6 more
wiley +1 more source
The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III. [PDF]
Brenda M. Herschbach +1 more
openalex +1 more source
DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding +5 more
wiley +1 more source
Mechanism of polyadenylation-independent RNA polymerase II termination. [PDF]
Rengachari S +4 more
europepmc +1 more source
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. [PDF]
Arik Dvir +4 more
openalex +1 more source
Light‐Harvesting Nanomaterials Based on Dyes for Energy Transfer and Amplified Biosensing
Light harvesting (LH) in plants inspires researchers to develop artificial LH nanomaterials. Here, LH nanomaterials based on organic dyes are reviewed, considering fundamental challenges on aggregation‐caused quenching, excitation energy transfer, and exciton migration length.
Andrey S. Klymchenko +2 more
wiley +1 more source
The Ser7 phosphorylation of RNA polymerase II-CTD is required for the recruitment of E3 ubiquitin ligase Asr1 and subtelomeric gene silencing. [PDF]
Sudarshan N +8 more
europepmc +1 more source

