Results 241 to 250 of about 821,958 (335)

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Proposal of Chemical Inhibitors That Compete with the Binding of RNA Polymerase II Subunits to Essential GTPases GPN Npa3 and Gpn1. [PDF]

ACS Omega
Muñiz-Luna JA, Santiago Á, Cristóbal-Mondragón GR, Calera MR, Sánchez-Olea R, Pastor N.   +5 more
europepmc   +1 more source

Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci

Claudia A. Mimoso, Hanneke Vlaming, Nathalie P. de Wagenaar, Karen Adelman   +3 more
openalex   +1 more source

Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution

, 2002
David Bushnell, Patrick Cramer, Roger D. Kornberg   +2 more
openalex   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets. [PDF]

Adv Sci (Weinh)
Wu W, Jiang H, Liu Y, Peng C, Wang H, Yang W, Lyu Z, Sun Y, Ma H, Gu H, Kan W, Jing L, Dong T, Xia C, Lei S, Wu R, Li J, Li J.   +17 more
europepmc   +1 more source

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair [PDF]

Goran Kokić, George Yakoub, Diana van den Heuvel, Annelotte P. Wondergem, Paula J. van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J. Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S. Luijsterburg   +12 more
openalex   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Nelfb promotes dermal white adipose tissue formation through RNA polymerase II-mediated adipogenic gene regulation. [PDF]

Development
Mahapatra S, Gomez J, Batzorig U, Liu Y, Fernández-Méndez C, Chen Y, Sen GL.   +6 more
europepmc   +1 more source

Figure S3 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer [PDF]

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain, Kexin Liu, Azadeh Arabzadeh, Yuxuan Qi, Yibo Xue, Leora Witkowski, Elise Graulich, Jutta Steinberger, Selim Mısırlıoğlu, Nicklas Bassani, Racim Sansal, Amber Yasmeen, Geneviève Morin, Jingjie Guo, Anie Monast, Virginie Pilon, Alica Valachová, Kitty Pavlakis, Lili Fu, Walter H. Gotlieb, W. Glenn McCluggage, David G. Huntsman, Alexander J.R. Bishop, Douglas A. Levine, Morag Park, Yemin Wang, Brian Raught, William D. Foulkes, Sidong Huang   +31 more
openalex   +1 more source