Results 241 to 250 of about 503,680 (311)

3D enhancer architecture coordinated by CTCF determines immune-related gene expression patterns via RNA polymerase II pause-release in CD4+ T cells. [PDF]

Nucleic Acids Res
Lee EC, Kim K, Kim S, Kim M, Kim HP.
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Olthof AM, Noe Gonzalez MJ, Poulsen NB, Moreno NN, Bautu T, Cugusi S, Svejstrup JQ.   +6 more
europepmc   +1 more source

The Ser7 phosphorylation of RNA polymerase II-CTD is required for the recruitment of E3 ubiquitin ligase Asr1 and subtelomeric gene silencing. [PDF]

J Biol Chem
Sudarshan N, Asalam M, Kumar A, Singh N, Gupta A, De I, Singh SK, Zhang KY, Akhtar MS.   +8 more
europepmc   +1 more source

Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5'- and 3' ends. [PDF]

Cell Rep
Luyties O, Sanford L, Rodino J, Nagel M, Jones T, Rimel JK, Ebmeier CC, Palacio M, Shelby GS, Cozzolino K, Brennan F, Hartzog A, Saucedo MB, Watts LP, Spencer S, Kugel JF, Dowell RD, Taatjes DJ.   +17 more
europepmc   +1 more source

Notch induces transcription by stimulating release of paused RNA polymerase II. [PDF]

Genes Dev
Rogers JM, Mimoso CA, Martin BJE, Martin AP, Aster JC, Adelman K, Blacklow SC.   +6 more
europepmc   +1 more source

Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II. [PDF]

Genome Biol
Rucli S, Descostes N, Ermakova Y, Chitnavis U, Couturier J, Boskovic A, Boulard M.   +6 more
europepmc   +1 more source

Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5

Sebesta M, Skubnik K, Morton W, Kravec M, Linhartova K, Klapstova V, Novacek J, Kubicek K, Bryja V, Vacha R, Stefl R.   +10 more
europepmc   +1 more source

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Sadurni MM, Jones ML, Pavlou L, Radi M, Kompocholi S, Passaretti P, Gambus A, Gregersen LH, Saponaro M.   +8 more
europepmc   +1 more source

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The RNA Polymerase II Core Promoter

Annual Review of Biochemistry, 2003
▪ Abstract  The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation.
Stephen T, Smale, James T, Kadonaga
openaire   +3 more sources