Results 291 to 300 of about 991,885 (339)

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Defining a chromatin architecture that supports transcription at RNA polymerase II promoters. [PDF]

J Biol Chem
Fisher MJ, Luse DS.
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila. [PDF]

Nucleic Acids Res
Zhang X, Liang SB, Yi Z, Qiao Z, Xu B, Geng H, Wang H, Yin X, Tang M, Ge W, Xu YZ, Liang K, Fan YJ, Chen L.   +13 more
europepmc   +1 more source

RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis. [PDF]

Cell Commun Signal
Pang SJ, Jiang TY, Wang NG, Cui XW, Wang H, Pan YF, Yang N, Dong LW.   +7 more
europepmc   +1 more source

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Sadurni MM, Jones ML, Pavlou L, Radi M, Kompocholi S, Passaretti P, Gambus A, Gregersen LH, Saponaro M.   +8 more
europepmc   +1 more source

Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7. [PDF]

J Virol
Whisnant AW, Dyck Dionisi O, Salazar Sanchez V, Rappold JM, Djakovic L, Grothey A, Marante AL, Fischer P, Peng S, Wolf K, Hennig T, Dölken L.   +11 more
europepmc   +1 more source

SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II. [PDF]

EMBO Rep
Ulferts S, Grosse R.
europepmc   +1 more source

RNA polymerase II transcription initiation in holo-TFIID-depleted mouse embryonic stem cells. [PDF]

Cell Rep
Hisler V, Bardot P, Detilleux D, Bernardini A, Stierle M, Sanchez EG, Richard C, Arab LH, Ehrhard C, Morlet B, Hadzhiev Y, Jung M, Le Gras S, Négroni L, Müller F, Tora L, Vincent SD.   +16 more
europepmc   +1 more source

The S-Phase Arrest of Host Cells Caused by an Alpha-Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes. [PDF]

Cell Prolif
Yang Q, Wu Y, Wang M, Chen S, Jia R, Yang Q, Zhu D, Liu M, Zhao X, Zhang S, Huang J, Ou X, Sun D, Tian B, He Y, Wu Z, Cheng A.   +16 more
europepmc   +1 more source