BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
doaj +1 more source
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. [PDF]
, 2017 Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress.
Angel Pujana, Miguel +29 more
core +2 more sources
Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation [PDF]
, 2013 Background: Transcription factors CREB, C/EBPβ and Jun regulate genes involved in keratinocyte proliferation and differentiation. We questioned if specific combinations of CREB, C/EBPβ and c-Jun bound to promoters correlate with RNA polymerase II binding,
Bhattacharya, Paramita +4 more
core +3 more sources
A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase. [PDF]
PLoS Computational Biology, 2013 The dynamics of the PPi release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive.
Lin-Tai Da +3 more
doaj +1 more source
Mechanistic insights into the transcriptional arrest in the presence of Double Strand Breaks [PDF]
, 2014 Double-strand breaks (DSBs) occur frequently in the genome during genome replication or by DNA damaging agents. DNA lesions affect fundamental DNA-dependent nuclear processes, such as replication and transcription.
Bonhomme, Celine +6 more
core +2 more sources
RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.
PLoS Genetics, 2020 RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino +10 more
doaj +1 more source
Estrogen-induced modification of uterine RNA polymerase activity depends on localization of the estrogen receptor [PDF]
Archives of Biological Sciences, 2007 The aim of this study was to examine the effects of estradiol (E2) on activity of RNA polymerase I and RNA polymerase II in uterine nuclei of ovariectomized (OVX) female rats.
Žakula Zorica +5 more
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
doaj +1 more source
A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]
, 2019 Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D. +2 more
core +1 more source