BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
doaj +1 more source
Actively transcribing RNA polymerase II concentrates on spliced leader genes in the nucleus of Trypanosoma cruzi [PDF]
, 2005 RNA polymerase II of trypanosomes, early diverging eukaryotes, transcribes long polycistronic messages, which are not capped but are processed by trans-splicing and polyadenylation to form mature mRNAs.
Dossin, Fernando de Macedo +1 more
core +3 more sources
RNA Polymerase II Transcription Elongation Control [PDF]
Chemical Reviews, 2013 Regulation of gene expression is critical in determining cell identity, development and responses to the cellular environment. DNA is the inherited source of genetic information and regulation of gene expression starts with the selection of which genes will undergo transcription.
Jiannan, Guo, David H, Price
openaire +2 more sources
Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation [PDF]
, 2013 Background: Transcription factors CREB, C/EBPβ and Jun regulate genes involved in keratinocyte proliferation and differentiation. We questioned if specific combinations of CREB, C/EBPβ and c-Jun bound to promoters correlate with RNA polymerase II binding,
Bhattacharya, Paramita +4 more
core +3 more sources
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]
, 2013 Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield +43 more
core +3 more sources
A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase. [PDF]
PLoS Computational Biology, 2013 The dynamics of the PPi release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive.
Lin-Tai Da +3 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
doaj +1 more source
RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.
PLoS Genetics, 2020 RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino +10 more
doaj +1 more source
Estrogen-induced modification of uterine RNA polymerase activity depends on localization of the estrogen receptor [PDF]
Archives of Biological Sciences, 2007 The aim of this study was to examine the effects of estradiol (E2) on activity of RNA polymerase I and RNA polymerase II in uterine nuclei of ovariectomized (OVX) female rats.
Žakula Zorica +5 more
doaj +1 more source