Results 41 to 50 of about 503,680 (311)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Sequential RNA polymerase II activation drives human hematopoiesis

Cell Reports
Summary: Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown.
Derek H. Janssens, Christine A. Codomo, Dominik J. Otto, Lev Silberstein, Kami Ahmad, Steve Henikoff   +5 more
doaj   +1 more source

Genome-wide control of RNA polymerase II activity by cohesin.

PLoS Genetics, 2013
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest ...
Cheri A Schaaf, Hojoong Kwak, Amanda Koenig, Ziva Misulovin, David W Gohara, Audrey Watson, Yanjiao Zhou, John T Lis, Dale Dorsett   +8 more
doaj   +1 more source

Estrogen-induced modification of uterine RNA polymerase activity depends on localization of the estrogen receptor [PDF]

Archives of Biological Sciences, 2007
The aim of this study was to examine the effects of estradiol (E2) on activity of RNA polymerase I and RNA polymerase II in uterine nuclei of ovariectomized (OVX) female rats.
Žakula Zorica, Isenović Esma R., Stojiljković Mojca, Korićanac G., Tepavčević Snežana, Ribarac-Stepić Nevena   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.

PLoS ONE, 2008
The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S.
Jessica L Dermody, Jonathan M Dreyfuss, Judit Villén, Babatunde Ogundipe, Steven P Gygi, Peter J Park, Alfred S Ponticelli, Claire L Moore, Stephen Buratowski, Miriam E Bucheli   +9 more
doaj   +1 more source

A Movie of RNA Polymerase II Transcription [PDF]

Cell, 2012
We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
openaire   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Iwr1 Directs RNA Polymerase II Nuclear Import [PDF]

Molecular Cell, 2011
RNA polymerase (Pol) II transcribes protein-coding genes in the nucleus of eukaryotic cells and consists of 12 polypeptide subunits. It is unknown how Pol II is imported into the nucleus. Here we show that Pol II nuclear import requires the protein Iwr1 and provide evidence for cyclic Iwr1 function.
Czeko, E., Seizl, M., Augsberger, C., Mielke, T., Cramer, P.   +4 more
openaire   +5 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source