Results 201 to 210 of about 186,287 (262)

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382. [PDF]

Cells
Das A, Yoshizawa T, Yamada D, Tsuyama T, Sato Y, Mizumoto T, Yoneshiro T, Kajimura S, Yamagata K.   +8 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Site-Specifically Modified Circular Ribonucleic Acid Serves as Multitarget miRNA Sponge with Low Immunogenicity. [PDF]

J Am Chem Soc
Pan Y, Li X, Zhou B, Zhuang Y, Luo L, Zhu C, Xu R, Jiang Y, Dong Y, Hao Z, Liu D, Zhang X.   +11 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Integrated analysis of transcriptome and metabolome reveals the molecular interactions and regulation of muscle flavor precursors in Tengchong Snow chickens and AA broilers. [PDF]

Front Vet Sci
Yang M, Zhang R, Zhao J, Jian Z, Wu H, Zi X, Wang K, Xu Z, Ge C, Jia J, Liu L, Dou T.   +11 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription. [PDF]

Redox Biol
Park SW, Choi CY, Park IB, Kang SJ, Lee HJ, Kim JI, Bae J, Geum D, Cheon YP, Chun T.   +9 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis. [PDF]

Front Cell Dev Biol
Yano JJ, Wei Z, Gajjar KJ, Barati-Stec KT, Yang E, Uyhazi KE.   +5 more
europepmc   +1 more source

T cell development from expanded hematopoietic progenitors reveals initiation control by <i>Lmo2</i> and Flt3L priming. [PDF]

Sci Immunol
Shin B, Chang SJ, MacNabb BW, Sidwell T, Williams BA, Rothenberg EV.   +5 more
europepmc   +1 more source