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Timing effciency in small-RNA-regulated post-transcriptional processes

Physical Review E, 2020
Gene regulation in a cellular environment is a stochastic phenomenon leading to a large variability in mRNAs and protein numbers that are often produced in bursts. The regulation leading to varied protein dynamics can be ascribed to transcriptional or post-transcriptional mechanisms.
Kuheli Biswas, Anandamohan Ghosh
openaire   +2 more sources

POST-TRANSCRIPTIONAL GENE REGULATION: RNA-PROTEIN INTERACTIONS, RNA PROCESSING, MRNA STABILITY AND LOCALIZATION

Biocomputing 2009, 2008
The goal of our workshop is to introduce some recent work in the area of post-transcriptional regulation to a wider computational community, discuss some of the unique computational problems faced in this area, and to present some preliminary solutions to these problems.
Benjamin, Blencowe   +3 more
openaire   +2 more sources

Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells

Biochemical Society Transactions, 2004
In HSV-1 (herpes simplex virus 1)-infected cells, the UL41 gene product carried with the virion has been shown to mediate the degradation of mRNA, leading to the shut-off of cellular protein synthesis. Analysis of the RNAs accumulating in cells infected with HSV-1 revealed the accumulation of RNAs encoding numerous cellular proteins both associated ...
B, Taddeo, A, Esclatine, B, Roizman
openaire   +2 more sources

Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease.

Trends in Molecular Medicine, 2020
Skeletal muscle formation is a complex process that requires tight spatiotemporal control of key myogenic factors. Emerging evidence suggests that RNA processing is crucial for the regulation of these factors, and that multiple post-transcriptional ...
Kaitlin Weskamp, B. Olwin, R. Parker
semanticscholar   +1 more source

Viral RNA in the cytoplasm of SV40-transformed mouse cells: Post-transcriptional processing

Virology, 1976
Abstract The virus-specific RNA present in the cytoplasmic and total cellular RNA of three standard and three flat lines of SV40-transformed mouse cells has been examined. The results using separated strands of the entire viral genome as hybridization probes indicate that extensive processing or selection of viral-specific RNA sequences occurs in ...
Leong, J C, Smith, H S, Goodman, H M
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Post-transcriptional addition of polyadenylic acid to mitochondrial RNA by a cordycepin-insensitive process

Journal of Molecular Biology, 1974
Abstract An RNA fraction in HeLa cell mitochondria has previously been shown to contain a small polyadenylic acid sequence (56 nucleotides) and to behave like messenger RNA. This fraction can be resolved into approximately eight distinct species which may be the messages for the mitochondrial-specified proteins.
M, Hirsch, S, Penman
openaire   +2 more sources

RNA processing in the male germline: Mechanisms and implications for fertility.

Seminars in Cell and Developmental Biology, 2017
Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction.
Julien M. D. Legrand, R. Hobbs
semanticscholar   +1 more source

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