Results 11 to 20 of about 160,310 (303)
Identification and RNA Binding Characterization of Plant Virus RNA Silencing Suppressor Proteins
Methods, 2013 Suppression is a common mechanism employed by viruses to evade the antiviral effects of the host’s RNA silencing pathway. The activity of suppression has commonly been localized to gene products in the virus, but the variety of mechanisms used in ...
Burch, Carissa J. +2 more
core +3 more sources
Deciphering the RNA Silencing Suppressor Function in the Potyvirus SPV2 [PDF]
Proceedings, 2020 In most eukaryotes, RNA silencing is a key element in the regulation of gene expression and defense against pathogens. Plants have developed a defensive barrier against exogenous microorganisms, such as plant-infecting viruses, by specifically targeting ...
Ornela Chase +2 more
doaj +3 more sources
Constrained peptides mimic a viral suppressor of RNA silencing [PDF]
Nucleic Acids Research, 2021 Abstract The design of high-affinity, RNA-binding ligands has proven very challenging. This is due to the unique structural properties of RNA, often characterized by polar surfaces and high flexibility. In addition, the frequent lack of well-defined binding pockets complicates the development of small molecule binders.
Arne Kuepper +11 more
openaire +8 more sources
Oomycete pathogens encode RNA silencing suppressors [PDF]
Nature Genetics, 2013 Effectors are essential virulence proteins produced by a broad range of parasites, including viruses, bacteria, fungi, oomycetes, protozoa, insects and nematodes. Upon entry into host cells, pathogen effectors manipulate specific physiological processes or signaling pathways to subvert host immunity.
Qiao, Yongli +14 more
openaire +3 more sources
Bacterial pathogens encode suppressors of RNA-mediated silencing [PDF]
Genome Biology, 2008 Plant pathogenic bacteria encounter host defenses mediated by a variety of small RNAs. Bacterial suppressors of silencing that inhibit multiple steps of plant microRNA biogenesis and function have recently been identified.
Mosher, Rebecca A, Baulcombe, David C
openaire +2 more sources
Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
core +2 more sources
Viral protein inhibits RISC activity by argonaute binding through conserved WG/GW motifs. [PDF]
PLoS Pathogens, 2010 RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins.
Ana Giner +4 more
doaj +1 more source
Frontiers in Microbiology, 2021 The 2b proteins encoded by cucumber mosaic virus (CMV) subgroup I strains suppress RNA silencing primarily by competitively binding small RNAs (sRNAs) in the host cell cytoplasm.
Yingying Gao +5 more
doaj +1 more source
Modelling the dynamics of viral suppressors of RNA silencing [PDF]
Journal of The Royal Society Interface, 2011 Virus infection in plants is limited by RNA silencing. In turn, viruses can counter RNA silencing with silencing suppressors. Viral suppressors of RNA silencing have been shown to play a role in symptom development in plants. We here study four different strategies employed by silencing suppressors: small interfering RNA (siRNA) binding, double-strand ...
Groenenboom, M.A.C., Hogeweg, P.
openaire +5 more sources
Viruses, 2015 Higher plants use RNA silencing to defend against viral infections. As a counter defense, plant viruses have evolved proteins that suppress RNA silencing.
Kishore K. Dey +4 more
doaj +1 more source