Results 221 to 230 of about 162,632 (256)
Nuclearly Encoded Splicing Factors Implicated in RNA Splicing in Higher Plant Organelles [PDF]
Molecular Plant, 2010 Plant organelles arose from two independent endosymbiosis events. Throughout evolutionary history, tight control of chloroplasts and mitochondria has been gained by the nucleus, which regulates most steps of organelle genome expression and metabolism.
Ian Small, Claire Lurin
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The role of RNA splicing factor PTBP1 in neuronal development
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct structures and functions from a single gene, is regulated by specific RNA-binding proteins and is an essential method for regulating gene expression in mammals. Recent studies have shown that abnormal change during neuronal development triggered by splicing mis-regulation
Hui-Lin, Liu +8 more
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Mutations of RNA splicing factors in hematological malignancies
Cancer Letters, 2017Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes.
Girish C. Shukla, Jagjit Singh
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Experimental Cell Research, 2003
Subcellular compartmentalization of splicing factors has been proposed to play a role in the regulation of alternative splicing. In the present work we have addressed this issue using adenovirus-infected cells to visualize an alternative splicing switch at the single cell level.
Gama-Carvalho, Margarida +2 more
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Subcellular compartmentalization of splicing factors has been proposed to play a role in the regulation of alternative splicing. In the present work we have addressed this issue using adenovirus-infected cells to visualize an alternative splicing switch at the single cell level.
Gama-Carvalho, Margarida +2 more
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The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice
Nature, 1999The production of correctly spliced messenger RNA requires two catalytic splicing steps. During step II, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3' splice site. This AG is usually located between 18 and 40 nucleotides downstream from the branch site, and closer AGs are skipped in favour of AGs located more optimally downstream.
K, Chua, R, Reed
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Nature Structural & Molecular Biology, 2006
Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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Characterization of a splicing mutation in the factor VIII gene at the RNA level
Human Genetics, 1995Haemophilia A is an X-linked bleeding disorder caused by mutations in the coagulation factor VIII (FVIII) gene. The identification and characterization of naturally occurring disease-producing mutations allows the recognition of new mechanisms of pathogenesis in haemophilia A. Analysis of the illegitimately transcribed FVIII mRNA in a severely affected
D, David, A, Tavares, J, Lavinha
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Alternatively spliced isoforms of a novel stromal RNA regulating factor
Gene, 2004Bone marrow stromal cells (MSC) are pluripotent cells that possess a unique capacity to differentiate under appropriate conditions into various lineages. The MSC differentiation is dependent on factors that can switch on and maintain a relevant genetic program to make a particular cell type.
I, Shur, D, Ben-Avraham, D, Benayahu
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Non-Canonical Functions of Splicing Factors in RNA Metabolism
Critical Reviews in Plant Sciences, 2020Noncoding RNA (ncRNA), such as microRNA (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) play roles in plant growth, development, and response to environmental cues via diverse manners...
Xiao Han +3 more
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