Results 221 to 230 of about 161,850 (258)

A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants

Applications in Plant Sciences, EarlyView.
Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk, Cintia F. Marchetti, Ezequiel Petrillo, Fernando A. Rabanal, Detlef Weigel, Nicolás Bellora, M. Verónica Arana   +6 more
wiley   +1 more source

Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review). [PDF]

Mol Med Rep
Zhang S, Li Z, Fu L.
europepmc   +1 more source

LncRSFD Alternative Splicing Modulates the Proliferation and Differentiation of Adipocytes Through Sponging miRNAs

Animal Research and One Health, EarlyView.
This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang, Qiuyang Li, Zhiying Wang, Shan Zhang, Kassahun Bekana, Qingfeng Zhang, Juanshan Zheng, Hongwei Xu, Xianyong Lan, Chuanying Pan   +9 more
wiley   +1 more source

Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing. [PDF]

Epigenetics Chromatin
Liu G, Cang J, Du Z, Cui X, Zhao H, Liu J.   +5 more
europepmc   +1 more source

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The role of RNA splicing factor PTBP1 in neuronal development

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023
Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct structures and functions from a single gene, is regulated by specific RNA-binding proteins and is an essential method for regulating gene expression in mammals. Recent studies have shown that abnormal change during neuronal development triggered by splicing mis-regulation
Hui-Lin, Liu, Xiu-Min, Lu, Hai-Yan, Wang, Kai-Bin, Hu, Qing-Yun, Wu, Ping, Liao, Sen, Li, Zai-Yun, Long, Yong-Tang, Wang   +8 more
openaire   +2 more sources

Nuclearly Encoded Splicing Factors Implicated in RNA Splicing in Higher Plant Organelles [PDF]

Molecular Plant, 2010
Plant organelles arose from two independent endosymbiosis events. Throughout evolutionary history, tight control of chloroplasts and mitochondria has been gained by the nucleus, which regulates most steps of organelle genome expression and metabolism.
Andéol Falcon De Longevialle, Ian Small, Claire Lurin   +2 more
exaly   +3 more sources

Mutations of RNA splicing factors in hematological malignancies

Cancer Letters, 2017
Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes.
Girish C. Shukla, Jagjit Singh
openaire   +2 more sources

Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleus

Experimental Cell Research, 2003
Subcellular compartmentalization of splicing factors has been proposed to play a role in the regulation of alternative splicing. In the present work we have addressed this issue using adenovirus-infected cells to visualize an alternative splicing switch at the single cell level.
Gama-Carvalho, Margarida, Condado, Inês, Carmo-Fonseca, Maria   +2 more
openaire   +3 more sources

The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice

Nature, 1999
The production of correctly spliced messenger RNA requires two catalytic splicing steps. During step II, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3' splice site. This AG is usually located between 18 and 40 nucleotides downstream from the branch site, and closer AGs are skipped in favour of AGs located more optimally downstream.
K, Chua, R, Reed
openaire   +2 more sources

Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells

Nature Structural & Molecular Biology, 2006
Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
openaire   +3 more sources