Results 231 to 240 of about 162,632 (256)

Identification of a family of DNA-binding proteins with homology to RNA splicing factors

Biochemistry and Cell Biology, 2006
We describe a unique family of human proteins that are capable of binding to the cAMP regulatory element (CRE) and that are homologous to RNA splicing proteins. A human cDNA was isolated that encodes a protein with a distinctive combination of modular domain structures: 2 leucine-zipper-like domains, a DNA-binding zinc-finger-like domain, an RNA ...
Kristy L, Shipman, Phillip J, Robinson, Bruce R, King, Roger, Smith, Richard C, Nicholson   +4 more
openaire   +2 more sources

Design of RNA-Binding Proteins: Manipulate Alternative Splicing in Human Cells with Artificial Splicing Factors

2016
The majority of human genes undergo alternative splicing to produce multiple isoforms with distinct functions. The dysregulations of alternative splicing have been found to be closely associated with various human diseases; thus new approaches to modulate disease-associated splicing events will provide great therapeutic potentials.
Yang, Wang, Zefeng, Wang
openaire   +2 more sources

The role of RNA splicing factors in the regulation of longevity

2021
Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I discovered that activity of RNA splicing factors REPO-1 and SFA-1 early in life, modulates effectiveness of known longevity interventions
openaire   +1 more source

The conserved role of RNA splicing factors in genome maintenance

2020
RNA splicing mutants have been broadly implicated in genome stability, but mechanistic links are often unclear. Two predominant models have emerged: one involving changes in gene expression that perturb other genome maintenance factors and another in which genotoxic DNA:RNA hybrids, called R-loops, impair DNA replication. Recent efforts in whole genome
openaire   +1 more source

Cell-type-specific splicing factors and the regulation of alternative RNA splicing.

The New biologist, 1991
A very wide variety of biological processes are regulated by alternative splicing. By this means, a gene can be transcribed in several different tissues but in each tissue the RNA transcript is spliced in a particular way to produce a different mRNA and hence a different protein.
openaire   +1 more source

A dual DNA/RNA-binding factor regulates co-transcriptional splicing through target RNA interaction and modulates splicing factor dynamics

Summary How RNA splicing events are targeted to the correct genomic locations in specific cellular contexts to generate context-specific transcript diversity and prevent deleterious cryptic splicing remains very poorly understood.
Mukulika Ray, Julia Zaborowsky, Pranav Mahableshwarkar, Smriti Vaidyanathan, Jasmine Shum, Annie Huang, Renjith Viswanathan, Isabelle Pilo, Victoria Chen, Kaitlyn Cortez, Ashley M. Conard, Szu-Huan Wang, Victoria Johnson, Noah Wake, Alexander E. Conicella, Ryan Puterbaugh, Nicolas L. Fawzi, Erica Larschan   +17 more
openaire   +1 more source

RNA splicing dysregulation and the hallmarks of cancer

Nature Reviews Cancer, 2023
Robert K Bradley, Olga Anczuków, Anczuków Olga   +2 more
exaly  

Dysregulation and therapeutic targeting of RNA splicing in cancer

Nature Cancer, 2022
Omar Abdel-Wahab, Robert Stanley, Abdel-Wahab Omar   +2 more
exaly  

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Cell, 2021
Benjamin Greenbaum, Jedd Wolchok, Harshal Shāh   +2 more
exaly  

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Cancer Cell, 2020
Luisa F Escobar-Hoyos, Direna Alonso Curbelo, Kenneth Shroyer   +2 more
exaly