Results 31 to 40 of about 156,310 (280)

RNA splicing factors regulated by HPV16 during cervical tumour progression [PDF]

The Journal of Pathology, 2009
AbstractThe most prevalent human papillomaviruses (HPVs) causing cervical disease are the ‘high‐risk’ HPV types 16 and 18. All papillomaviruses express a transcription factor, E2, that can regulate viral and cellular gene expression. Recently, we demonstrated high‐risk HPV E2‐mediated transcriptional transactivation of SF2/ASF.
Mole, S., McFarlane, M., Chuen-Im, T., Milligan, S.G., Millan, D., Graham, S.V.   +5 more
openaire   +3 more sources

RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins

Cell Reports, 2018
Summary: RNA splicing entails the coordinated interaction of more than 150 proteins in the spliceosome, one of the most complex of the cell’s molecular machines.
Antonia De Maio, Hari Krishna Yalamanchili, Carolyn J. Adamski, Vincenzo A. Gennarino, Zhandong Liu, Jun Qin, Sung Y. Jung, Ronald Richman, Harry Orr, Huda Y. Zoghbi   +9 more
doaj   +1 more source

Exploring RNA modifications, editing, and splicing changes in hyperuricemia and gout

Frontiers in Medicine, 2022
Hyperuricemia and gout are two of the most common metabolic disorders worldwide; their incidence is increasing with changes in lifestyle, and they are correlated with many diseases, including renal and cardiovascular diseases.
Chung-Ming Huang, Chung-Ming Huang, Chung-Ming Huang, Yu-Chia Chen, Yu-Chia Chen, Yu-Chia Chen, I-Lu Lai, I-Lu Lai, Hong-Da Chen, Po-Hao Huang, Siang-Jyun Tu, Ya-Ting Lee, Ya-Ting Lee, Ju-Chen Yen, Ju-Chen Yen, Chia-Li Lin, Chia-Li Lin, Ting-Yuan Liu, Ting-Yuan Liu, Ting-Yuan Liu, Jan-Gowth Chang, Jan-Gowth Chang   +21 more
doaj   +1 more source

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides [PDF]

Nature Communications, 2019
AbstractAlternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs.
Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D. Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Frédéric H. Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni   +14 more
openaire   +3 more sources

FMRP deficiency leads to multifactorial dysregulation of splicing and mislocalization of MBNL1 to the cytoplasm.

PLoS Biology, 2023
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is often modeled in Fmr1 knockout mice where the RNA-binding protein FMRP is absent. Here, we show that in Fmr1-deficient mice, RNA mis-splicing occurs in several brain regions and peripheral
Suna Jung, Sneha Shah, Geongoo Han, Joel D Richter   +3 more
doaj   +1 more source

The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. [PDF]

PLoS Genetics, 2012
RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre-mRNA, alternative splicing plays a key role in promoting the evolving complexity of metazoans.
Long Ma, Xiaoyang Gao, Jintao Luo, Liange Huang, Yanling Teng, H Robert Horvitz   +5 more
doaj   +1 more source

The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly

Cell Reports, 2017
Summary: RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known as ...
An-Yun Chang, Stephane E. Castel, Evan Ernst, Hyun Soo Kim, Robert A. Martienssen   +4 more
doaj   +1 more source

Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2 [PDF]

Journal of Cell Science, 2007
The scaffold attachment factor SAFB1 and its recently discovered homologue SAFB2 might provide an important link between pre-mRNA splicing, intracellular signalling and transcription. Using novel mono-specific antisera, we found endogenous SAFB2 protein has a different spatial distribution from SAFB1 within the nucleus where it is found in much larger ...
Sergeant KA, Bourgeois CF, Dalgliesh C, Venables JP, Stevenin J, Elliott DJ   +5 more
openaire   +3 more sources

Pre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing Process

Biomolecules, 2015
Alternative pre-messenger RNA splicing in higher plants emerges as an important layer of regulation upon exposure to exogenous and endogenous cues. Accordingly, mutants defective in RNA-binding proteins predicted to function in the splicing process show ...
Katja Meyer, Tino Koester, Dorothee Staiger   +2 more
doaj   +1 more source

Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. [PDF]

PLoS ONE, 2011
We have previously identified an Alu-derived Intronic Splicing enhancer (ISE) in the Ataxia Teleangectasia Mutated gene (ATM) that facilitates intron pre-mRNA processing and leads to the inclusion of a cryptic exon in the final mRNA transcript.
Tibor Pastor, Franco Pagani
doaj   +1 more source