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Editorial: Plant RNA structure [PDF]

Frontiers in Plant Science, 2023
Huakun Zhang, Betty Y.-W. Chung, Zhiye Wang, Yiliang Ding   +3 more
doaj   +4 more sources

RNA structure determination: From 2D to 3D [PDF]

Fundamental Research, 2023
RNA molecules serve a wide range of functions that are closely linked to their structures. The basic structural units of RNA consist of single- and double-stranded regions.
Jie Deng, Xianyang Fang, Lin Huang, Shanshan Li, Lilei Xu, Keqiong Ye, Jinsong Zhang, Kaiming Zhang, Qiangfeng Cliff Zhang   +8 more
doaj   +2 more sources

Unveiling RNA structure-mediated regulations of RNA stability in wheat [PDF]

Nature Communications
Despite the critical role of mRNA stability in post-transcriptional gene regulation, research on this topic in wheat, a vital agricultural crop, remains unclear. Our study investigated the mRNA decay landscape of durum wheat (Triticum turgidum L.
Haidan Wu, Haopeng Yu, Yueying Zhang, Bibo Yang, Wenqing Sun, Lanying Ren, Yuchen Li, Qianqian Li, Bao Liu, Yiliang Ding, Huakun Zhang   +10 more
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Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs

RNA Biology, 2022
RNA translation is the rate-limiting step when cells synthesize proteins. Elevating translation efficiency (TE) is intuitively beneficial. Particularly, when viruses invade host cells, how to compete with endogenous RNAs for efficient translation is a ...
Lin Zhu, Qi Wang, Weiyu Zhang, Hao Hu, Kexin Xu   +4 more
doaj   +1 more source

Deconstructing internal ribosome entry site elements: an update of structural motifs and functional divergences [PDF]

Open Biology, 2018
Beyond the general cap-dependent translation initiation, eukaryotic organisms use alternative mechanisms to initiate protein synthesis. Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote internal initiation of ...
Gloria Lozano, Rosario Francisco-Velilla, Encarnacion Martinez-Salas   +2 more
doaj   +1 more source

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

RNA Biology, 2022
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu   +6 more
doaj   +1 more source

Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch

Nature Communications, 2023
T-box riboswitches are unique riboregulators where gene regulation is mediated through interactions between two highly structured RNAs. Despite extensive structural insights, how RNA-RNA interactions drive the folding and structural transitions of T-box ...
Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen, Xianyang Fang   +5 more
doaj   +1 more source

Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer

Pharmaceutics, 2023
Triple-negative breast cancer (TNBC) is a life-threatening form of breast cancer which has been found to account for 15% of all the subtypes of breast cancer.
Rajesh Pradhan, Anuradha Dey, Rajeev Taliyan, Anu Puri, Sanskruti Kharavtekar, Sunil Kumar Dubey   +5 more
doaj   +1 more source

Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions

Non-Coding RNA, 2021
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation.
Ilias Skeparnias, Jinwei Zhang
doaj   +1 more source

An RNA Thermometer Activity of the West Nile Virus Genomic 3′-Terminal Stem-Loop Element Modulates Viral Replication Efficiency during Host Switching

Viruses, 2020
The 3′-terminal stem-loop (3′SL) of the RNA genome of the flavivirus West Nile (WNV) harbors, in its stem, one of the sequence elements that are required for genome cyclization.
Alexandra Meyer, Marie Freier, Tobias Schmidt, Katja Rostowski, Juliane Zwoch, Hauke Lilie, Sven-Erik Behrens, Susann Friedrich   +7 more
doaj   +1 more source