Results 31 to 40 of about 541,018 (257)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The alphaviruses: gene expression, replication, and evolution [PDF]

, 1994
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
core   +1 more source

Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes

, 2008
By performing a comprehensive study on 1832 segments of 1212 complete genomes of viruses, we show that in viral genomes the hairpin structures of thermodynamically predicted RNA secondary structures are more abundant than expected under a simple random ...
A. Tuplin, C. Thurner, D.S.H. Chew, F. Lillo, F. Lillo, F. Lillo, F. Ratcliff, G.P. Schroth, H.O. Smith, J.S. Mattick, M. Spanò, M. Spanò, M.Y. Leung, P. Rice, P. Simmonds, P.E. Warburton, R. Cox, R. N. Mantegna, R.C. Lee, S. Miccichè, S.R. Eddy   +20 more
core   +1 more source

Kinetics of viral self-assembly: the role of ss RNA antenna [PDF]

, 2007
A big class of viruses self-assemble from a large number of identical capsid proteins with long flexible N-terminal tails and ss RNA. We study the role of the strong Coulomb interaction of positive N-terminal tails with ss RNA in the kinetics of the in ...
B. I. Shklovskii, D. F. Evans, M. V. Smoluchowski, S. Campbell, S. Campbell, S. J. Flint, Tao Hu   +6 more
core   +1 more source

Discovering the Phylodynamics of RNA Viruses

PLoS Computational Biology, 2009
1 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania, United States of America, 2 Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Department of Ecology and Evolutionary Biology and Woodrow Wilson ...
Edward C. Holmes, Bryan T. Grenfell, Bryan T. Grenfell   +2 more
openaire   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source