Results 41 to 50 of about 836,536 (329)
Uni-directional polymerization leading to homochirality in the RNA world [PDF]
, 2005 The differences between uni-directional and bi-directional polymerization are considered. The uni-directional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bi-
Andersen, A. C. +3 more
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Methanol in the RNA world: An astrochemical perspective
Frontiers in Astronomy and Space Sciences, 2022 The role and relevance of methanol in the origin and structure of the RNA world is discussed. Methanol is a pivotal, renewable, and regenerable source from which almost all chemical materials, simple or complex, can be accessed.
Thomas Mathew +2 more
doaj +1 more source
Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]
, 2014 Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny +5 more
core +1 more source
Acta Societatis Botanicorum Poloniae, 2014 Among the numerous hypotheses offering a scenario for the origin of life on Earth, the one called “The RNA World” has gained the most attention. According to this hypothesis RNA acted as a genetic information storage material, as a catalyst of all ...
Zofia Szweykowska-Kulińska
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The new world of RNA diagnostics and therapeutics
Journal of Experimental & Clinical Cancer Research, 2023 The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in ...
Giovanni Blandino +18 more
doaj +1 more source
The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]
, 2017 This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core +2 more sources
RNA Vaccine: novel approach for cancer treatment [PDF]
, 2011 Cancer is still an unsolved puzzle and a major cause of mortality and morbidity in the world. Today, about one in every thousand people is dying due to cancer. No effective agent has yet been found which can cure cancer in its metastatic stage.
Kanika Bhalla +2 more
core +2 more sources
The RNA World: 4,000,000,050 years old
Life, 2015 The RNA World is now some four billion years behind us, but only recently turned 50 as a human hypothesis. [...]
Niles Lehman
doaj +1 more source
Os semimetais na origem e evolução da vida
Química Nova, 2012 Metalloids have characteristics between metals and non-metals which give them, in some cases, specific properties. At least two of this chemical elements, boron and silicon, are essential to a significant number of living organisms and since some years ...
Manuel Aureliano +3 more
doaj +1 more source
A Faster Triphosphorylation Ribozyme. [PDF]
, 2015 In support of the RNA world hypothesis, previous studies identified trimetaphosphate (Tmp) as a plausible energy source for RNA world organisms. In one of these studies, catalytic RNAs (ribozymes) that catalyze the triphosphorylation of RNA 5'-hydroxyl ...
Akoopie, Arvin +2 more
core +4 more sources