Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. [PDF]
PLoS ONE, 2011 It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions.
Liang Shen, Hong-Fang Ji
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Chiral polymerization and the RNA world [PDF]
International Journal of Astrobiology, 2005 The purpose of this paper is to review two mathematical models: one for the formation of homochiral polymers from an originally chirally symmetric system; and the other, to show how, in an RNA-world scenario, RNA can simultaneously act both as information storage and a catalyst for its own production.
Wattis, Jonathan A.D., Coveney, Peter V.
openaire +4 more sources
Life, 2015 How could modern life have evolved? The answer to that question still remains unclear. However, evidence is growing that, since the origin of life, RNA could have played an important role throughout evolution, right up to the development of complex ...
Darko Balke +2 more
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Twenty years of "Lipid World": a fertile partnership with David Deamer [PDF]
, 2019 "The Lipid World" was published in 2001, stemming from a highly effective collaboration with David Deamer during a sabbatical year 20 years ago at the Weizmann Institute of Science in Israel.
Kahana, Amit +2 more
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]
, 1998 Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
core
Arginine cofactors on the polymerase ribozyme. [PDF]
PLoS ONE, 2011 The RNA world hypothesis states that the early evolution of life went through a stage in which RNA served both as genome and as catalyst. The central catalyst in an RNA world organism would have been a ribozyme that catalyzed RNA polymerization to ...
Chengguo Yao +4 more
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One-Pot Formation of Pairing Proto-RNA Nucleotides and Their Supramolecular Assemblies
Life, 2023 Most contemporary theories for the chemical origins of life include the prebiotic synthesis of informational polymers, including strong interpretations of the RNA World hypothesis.
Tyler P. Roche +4 more
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In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]
, 2011 According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan +2 more
core +1 more source
, 2012 The evolution of life has been a big enigma despite rapid advancements in the fields of biochemistry, astrobiology, and astrophysics in recent years.
A. Gibbons +46 more
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