Results 211 to 220 of about 370,027 (271)

Viroid-like "obelisk" agents are widespread in the ocean and exceed the abundance of RNA viruses in the prokaryotic fraction. [PDF]

ISME J
López-Simón J, de la Peña M, Martínez-García M.   +2 more
europepmc   +1 more source

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

Codepoietic Generation of Meaningful Information in the Evolving Biosphere. [PDF]

Entropy (Basel)
Igamberdiev AU.
europepmc   +1 more source

A Modular Perfusion Bioreactor Platform for Simulating Bone Regeneration and Fracture Healing: Integrating Mechanical Loading and Dual Perfusion for Advanced In Vitro Models

Advanced Healthcare Materials, EarlyView.
A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger, Alexandra Damerau, Johannes Plank, Adel Ahmed, Mario Thiele, Jan Saam, Paula Hoff, Timo Gaber, Frank Buttgereit   +8 more
wiley   +1 more source

The Expanding Universe of Extensions and Tails: Ribosomal Proteins and Histones in RNA and DNA Complex Signaling and Dynamics. [PDF]

Genes (Basel)
Timsit Y.
europepmc   +1 more source

3D Bioprinting‐Assisted Engineering of Stem Cell‐Laden Hybrid Biopatches With Distinct Geometric Patterns Considering the Mechanical Characteristics of Regular and Irregular Connective Tissues

Advanced Healthcare Materials, EarlyView.
A hybrid biopatch platform integrating 3D printed polymeric patterns with stem cell‐laden collagen bioinks is developed to mimic the mechanical properties of connective tissues. By tailoring geometric architectures, the constructs replicate anisotropic or isotropic mechanics, enhancing tissue‐specific regeneration.
Minjun Ahn, Gyu Tae Park, Arvind Kumar Shukla, Boguen Kwon, Jae Ho Kim, Eui‐Suk Sung, Byoung Soo Kim   +6 more
wiley   +1 more source

DiSC: a statistical tool for fast differential expression analysis of individual-level single-cell RNA-seq data. [PDF]

Bioinformatics
Zhang L, Yang L, Ren Y, Zhang S, Guan W, Chen J.   +5 more
europepmc   +1 more source

Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis

Advanced Healthcare Materials, EarlyView.
Crypt‐villi‐like morphogenesis can be driven and controlled via architectural patterns in colorectal cells with the use of digital light processing printing. The resulting mini tissues exhibit budding structures and functionality, as evidenced by increased mucin expression.
Nathaniel C. Burmas, Arlyn M. Fabian, Amoli Vanavadiya, Quinton Smith   +3 more
wiley   +1 more source

Clinical applications of and molecular insights from RNA sequencing in a rare disease cohort. [PDF]

Genome Med
Stark JC, Pipko N, Liang Y, Szuto A, Tsoi CT, Dickson MA, Yuki KE, Hou H, Scholten S, Pulsifer K, Acker M, Laver M, Murthy H, Moran OM, Bonnell E, Liang N, Sidhu J, Dupuis L, Seno MMG, Care4Rare Canada Consortium, Chard M, Jobling RK, Cameron J, Chami R, Inbar-Feigenberg M, Wilson MD, Chitayat DA, Boycott KM, Kyriakopoulou L, Mendoza-Londono R, Marshall CR, Dowling JJ, Costain G, Deshwar AR.   +33 more
europepmc   +1 more source

Magnetic Resonance Imaging‐Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle‐Loaded Lipid Nanoparticles

Advanced Healthcare Materials, EarlyView.
The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee, Jeongbin Park, Han Na Jung, Shengjun Li, Zhijun Lin, Hyung‐Jun Im   +5 more
wiley   +1 more source