Results 121 to 130 of about 323,847 (388)

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

RNAi in Insects: A Revolution in Fundamental Research and Pest Control Applications

Insects, 2020
In this editorial for the Special Issue on ‘RNAi in insect pest control’, three important applications of RNA interference (RNAi) in insects are briefly discussed and linked to the different studies published in this Special Issue.
O. Christiaens, J. Niu, Clauvis Nji Tizi Taning   +2 more
semanticscholar   +1 more source

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

Advanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuan   +9 more
wiley   +1 more source

PhSLB1 Regulates Branch Development in Petunia

Journal of the American Society for Horticultural Science
F-box proteins play crucial roles in various developmental stages in plants, such as shoot branching. As an important ornamental and model plant, the branch development of petunia has always been a hot research topic. In our study, the homologous gene of
Jichu Deng, Xinyi Deng, Mengyu Zhang, Ziyan Tang, Lili Dong   +4 more
doaj   +1 more source

Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits

G3: Genes, Genomes, Genetics, 2019
Physiology, fitness and disease phenotypes are complex traits exhibiting continuous variation in natural populations. To understand complex trait gene functions transgenic lines of undefined genetic background are often combined to assess quantitative ...
Amalia Evangelou, Anastasia Ignatiou, Chloi Antoniou, Sofia Kalanidou, Sotiroula Chatzimatthaiou, Gavriella Shianiou, Soteroulla Ellina, Rafaella Athanasiou, Myrofora Panagi, Yiorgos Apidianakis, Chrysoula Pitsouli   +10 more
doaj   +1 more source

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans [PDF]

, 2018
Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic
Artal Sanz, Marta, Askjaer, Peter, Baumeister, Ralf, Erinjeri, Annmary Paul, González Hernández, Sara, Hernando Rodríguez, Blanca, Millar, Val, Muñoz, Manuel J., Olmedo López, María, Rodríguez Palero, María Jesús, Schulze, Bettina   +10 more
core   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Antiviral therapy in shrimp through plant virus VLP containing VP28 dsRNA against WSSV

Beilstein Journal of Organic Chemistry, 2021
The white spot syndrome virus (WSSV), currently affecting cultured shrimp, causes substantial economic losses to the worldwide shrimp industry. An antiviral therapy using double-stranded RNA interference (dsRNAi) by intramuscular injection (IM) has ...
Santiago Ramos-Carreño, Ivone Giffard-Mena, Jose N. Zamudio-Ocadiz, Alfredo Nuñez-Rivera, Ricardo Valencia-Yañez, Jaime Ruiz-Garcia, Maria Teresa Viana, Ruben D. Cadena-Nava   +7 more
doaj   +1 more source

Assessment of RNAi-induced silencing in banana (Musa spp.) [PDF]

, 2015
In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements.
Cammue, B.P.A., Coninck, B. de, Dang Thi Tuong Vi, Henry, I., Remy, S., Swennen, Rony L., Windelinckx, S.   +6 more
core   +1 more source

E-RNAi: a web application to design optimized RNAi constructs [PDF]

Nucleic Acids Research, 2005
RNA interference (RNAi) has become a powerful genetic approach to systematically dissect gene function on a genome-wide scale. Owing to the penetrance and efficiency of RNAi in invertebrates, model organisms such as Drosophila melanogaster and Caenorhabditis elegans have contributed significantly to the identification of novel components of diverse ...
Zeynep Arziman, Thomas Horn, Michael Boutros   +2 more
openaire   +5 more sources