Results 121 to 130 of about 195,676 (344)

Pathological Disulfide Bond Crosslinking: Molecular Insights into Amyloidogenesis and Diseases Progression

ChemBioChem, EarlyView.
This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang, Nataliia Lukianenko, Ja‐Hyun Baik, Yun Kyung Kim, Sungsu Lim   +4 more
wiley   +1 more source

Elucidating the Pathogenic Mechanism of Spinal Muscular Atrophy Through the Investigation of UTS2

Frontiers in Bioscience-Landmark
Background: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene, resulting in progressive motor neuron loss and muscle atrophy.
Xu Zhang, Liqi Yang
doaj   +1 more source

PIN domains in nonsense-mediated mRNA decay and RNAi [PDF]

, 2000
Patricia M. Clissold, Chris P. Ponting
openalex   +1 more source

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The RNA interference (RNAi) discovered in nematodes has contributed to major advances in basic and applied sciences. RNAi-based methods are being developed for controlling pests and disease vectors.
June-Sun Yoon, Kanakachari Mogilicherla, D. Gurusamy, Xien Chen, Shankar C. R. R. Chereddy, S. R. Palli   +5 more
semanticscholar   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Plant Growth Promoting Microorganisms and Emerging Biotechnological Approaches for Sugarcane Disease Management

Journal of Pure and Applied Microbiology
Sugarcane (Saccharum officinarum L.) is a highly valuable agricultural crop, cultivated globally in tropical and subtropical regions, primarily for its sugar content.
J. Jernisha, R. Poorniammal, U. Sivakumar, S. Harish, K. Sethuraman   +4 more
doaj   +1 more source

RNAi of the receptor tyrosine phosphatase Hm LAR2 in a single cell of an intact leech embryo leads to growth-cone collapse [PDF]

, 2000
Michael W. Baker, Eduardo R. Macagno
openalex   +1 more source

Role of TREM1 in the sevoflurane‐induced inflammatory activation of microglia in vitro

Ibrain, EarlyView.
Perioperative neurocognitive disorders (PNDs) are one of the most common complications in perioperative patients, and neuroinflammatory reaction mediated by microglia plays a key role in their formation. Triggering receptor expressed on myeloid cells 1 (TREM1) is a key regulator of inflammation.
Chunchun Tang, Yuhang Zhu, Dexing Liu, Xue Zheng, Junli Jiang, Wanqiu Yu, Yinan Zhang, Dongqin Chen, Zhaoqiong Zhu   +8 more
wiley   +1 more source

RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans [PDF]

, 2000
Fabio Piano, Aaron J. Schetter, Marco Mangone, Lincoln Stein, Kenneth J. Kemphues   +4 more
openalex   +1 more source

Targeting the ST3 beta‐galactoside alpha‐2,3‐sialyltransferase 1 (ST3Gal1) as a potential therapeutic strategy to overcome anti‐VEGF resistance in endometrial cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 beta‐galactoside alpha‐2,3‐sialyltransferase 1 (ST3Gal1) in endometrial cancer (EC) progression and its potential as a therapeutic target to enhance the efficacy of antiangiogenic treatment. Methods ST3Gal1 expression and its clinical relevance were analyzed in EC tissues.
Chia‐Hao Liu, Szu‐Ting Yang, Wei‐Ting Chao, Chen‐Hao Lin, Yu‐Chieh Lee, Chiung‐Ru Lai, Shie‐Liang Hsieh, Liang‐Wei Wang, Peng‐Hui Wang   +8 more
wiley   +1 more source