Results 131 to 140 of about 195,676 (344)
CRISPR/Cas9 Knockout of Shell Matrix Protein 1 in the Slipper‐Snail Crepidula atrasolea
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Methods for CRISPR/Cas9 shell matrix protein knockout in the snail, Crepidula atrasolea including optimizing RNP delivery and embryo husbandry, to the use of Sanger and MiSeq sequencing, and high‐content screening of embryos to characterize the loss of Shell Matrix Protein 1 (SMP1) during larval shell development.
Grant Batzel +13 more
wiley +1 more source
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger +6 more
wiley +1 more source
Gene and Genome Duplication in Spiders
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In chelicerates whole genome duplications (WGDs) were identified in distinct groups. While there is evidence that Xiphosurans/horseshoe crabs had three rounds of WGD and arachnopulmonates (e.g. spiders and scorpions) had one WGD, in many other arachnid groups no WGD was identified.
Chetan Munegowda +3 more
wiley +1 more source
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Nature, 2003 R. Kamath +12 more
semanticscholar +1 more source
D-RNAi (Messenger RNA-antisense DNA Interference) as a Novel Defense System Against Cancer and Viral Infections. [PDF]
, 2001 Shuei‐Liong Lin +4 more
openalex +1 more source
Molecular Nutrition &Food Research, EarlyView.Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García +4 more
wiley +1 more source
Evaluation of TRPA1 as a Therapeutic Target in MYCN‐Amplified Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neuroblastoma (NB) is a childhood cancer with a high relapse rate despite intensive treatment. TRPA1 is a pain‐sensing ion channel with downstream impacts on proliferative and pro‐apoptotic pathways. Here, we evaluated TRPA1 expression in NB and performed pharmacological inhibition in preclinical models to assess its potential as a ...
Alexandra Seger +13 more
wiley +1 more source