Results 231 to 240 of about 323,847 (388)

Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction

Glia, EarlyView.
When cortex glia lose their interactions with neuronal cell bodies, all neighboring glia infiltrate the region to clear extra neuronal corpses. Even while compensating for nearby glial dysfunction, glia maintain their own phagocytic functions. ABSTRACT Glial cells are essential for nervous system development, homeostasis, and disease response, engaging
Allison N. Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus Weigel, Lydia Ambaye, Hayes Miller, Hannah Grote, Jaeda Coutinho‐Budd   +13 more
wiley   +1 more source

The functional <i>Mi-2/Foxo</i> complex targets <i>PGRP-SC2</i> for the <i>Drosophila</i> immune defense against bacterial infection. [PDF]

Front Immunol
Zheng X, Ali U, Jin Y, Ding E, Zhu Y, Usama M, Cai Q, Ji S.   +7 more
europepmc   +1 more source

Role of TREM1 in the sevoflurane‐induced inflammatory activation of microglia in vitro

Ibrain, EarlyView.
Perioperative neurocognitive disorders (PNDs) are one of the most common complications in perioperative patients, and neuroinflammatory reaction mediated by microglia plays a key role in their formation. Triggering receptor expressed on myeloid cells 1 (TREM1) is a key regulator of inflammation.
Chunchun Tang, Yuhang Zhu, Dexing Liu, Xue Zheng, Junli Jiang, Wanqiu Yu, Yinan Zhang, Dongqin Chen, Zhaoqiong Zhu   +8 more
wiley   +1 more source

Short hairpin type of dsRNAs that are controlled by tRNAVal promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells [PDF]

, 2003
Hiroshi Kawasaki
openalex   +1 more source

Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms. [PDF]

PLoS Biol
Mallik B, Bhat SA, Wang X, Frank CA.
europepmc   +1 more source

Pathogen Response Genes Mediate Caenorhabditis elegans Innate Immunity

, 2012
Innate immunity is crucial in the response and defense against pathogens for invertebrates and vertebrates alike. The soil nematode Caenorhabditis elegans is a useful model to study the eukaryotic innate immune response to microbial pathogenesis.
Anthony, Hannah L.
core  

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, EarlyView.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

A chemical‐regulated inducible RNAi system in plants [PDF]

, 2003
Hui‐Shan Guo, Ji‐Feng Fei, Qi Xie, Nam‐Hai Chua   +3 more
openalex   +1 more source

CmVNI2-CmMYB3 module regulates flavonol biosynthesis in response to low temperature in chrysanthemum flower. [PDF]

Mol Hortic
Jiang T, Sun Y, Wang Y, Luo J, Liu L, Chen H, Xue Y, Wang L, Gao K, Chen D, Ma C, Huang C, Luo C.   +12 more
europepmc   +1 more source

Targeting the ST3 beta‐galactoside alpha‐2,3‐sialyltransferase 1 (ST3Gal1) as a potential therapeutic strategy to overcome anti‐VEGF resistance in endometrial cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 beta‐galactoside alpha‐2,3‐sialyltransferase 1 (ST3Gal1) in endometrial cancer (EC) progression and its potential as a therapeutic target to enhance the efficacy of antiangiogenic treatment. Methods ST3Gal1 expression and its clinical relevance were analyzed in EC tissues.
Chia‐Hao Liu, Szu‐Ting Yang, Wei‐Ting Chao, Chen‐Hao Lin, Yu‐Chieh Lee, Chiung‐Ru Lai, Shie‐Liang Hsieh, Liang‐Wei Wang, Peng‐Hui Wang   +8 more
wiley   +1 more source