Results 21 to 30 of about 323,847 (388)
Communications Biology, 2021 Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells.
Basudeb Das +2 more
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi [PDF]
Journal of Visualized Experiments, 2010 RNA interference (RNAi) represents a high effective mechanism for specific inhibition of mRNA expression. Besides its potential as a powerful laboratory tool, the RNAi pathway appears to be promising for therapeutic utilization. For development of RNA interference (RNAi)-based therapies, delivery of RNAi-mediating agents to target cells is one of the ...
Hermann Lage, Andrea Krühn
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Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
semanticscholar +1 more source
Developmental Cell, 2011 Small non-coding RNAs, through association with Argonaute protein family members, have a variety of functions during the development of an organism. Although there is increased mechanistic understanding of the RNA interference (RNAi) pathways surrounding these small RNAs, how their effects are modulated by subcellular compartmentalization and cross ...
René F. Ketting, René F. Ketting
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Insight Into the Prospects for RNAi Therapy of Cancer
Frontiers in Pharmacology, 2021 RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic ...
Zhili Tian +7 more
semanticscholar +1 more source
Asian Citrus Psyllid RNAi Pathway – RNAi evidence [PDF]
Scientific Reports, 2016 AbstractDiaphorina citri, known as the Asian citrus psyllid, is an important pest of citrus because it transmits a phloem-limited bacteria strongly implicated in huanglongbing (citrus greening disease). Emerging biotechnologies, such as RNA interference, could provide a new sustainable and environmentally friendly strategy for the management of this ...
Taning, Nji Tizi Clauvis +4 more
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RNAi in Clinical Studies [PDF]
Current Medicinal Chemistry, 2013 RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
Paulina Kubowicz +2 more
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Mapping the Salt Stress-Induced Changes in the Root miRNome in Pokkali Rice
Biomolecules, 2020 A plant’s response to stress conditions is governed by intricately coordinated gene expression. The microRNAs (miRs) have emerged as relatively new players in the genetic network, regulating gene expression at the transcriptional and post ...
Kavita Goswami +4 more
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Identification and functional analysis of a testis‑biased gene encoding serine/arginine‑rich protein in silkworm, Bombyx mori [PDF]
Archives of Biological Sciences, 2019 Spermatogenesis is a fundamental process in sexual reproduction. In this study, we cloned a 716-bp cDNA of a testis-biased gene in Bombyx mori, named as BmRS-TS, which encodes a polypeptide of 164 amino acids, containing 26.7% arginine and serine ...
Zhang Li-Ying, Li Juan, Zha Xing-Fu
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Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]
, 2015 UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson +4 more
core +5 more sources