Results 21 to 30 of about 195,676 (344)
A Perspective on RNAi-Based Biopesticides
Frontiers in Plant Science, 2020 Sustainable agriculture relies on practices and technologies that combine effectiveness with a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which transcript expression is reduced in a sequence-specific manner, can be ...
Stephen J. Fletcher +3 more
semanticscholar +1 more source
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
New England Journal of Medicine, 2018 BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with ...
D. Adams +35 more
semanticscholar +1 more source
Developmental Cell, 2005 Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the ...
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RNAi in Clinical Studies [PDF]
Current Medicinal Chemistry, 2013 RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
Paulina Kubowicz +2 more
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International Journal of Molecular Sciences, 2021 RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and emerging evidence that spray-induced gene silencing (SIGS) techniques
Alejandro Hernández-Soto +1 more
semanticscholar +1 more source
Molecular Therapy, 2011 A recurring theme in the way that many pharmaceutical companies approach new technologies is that they are initially extremely enthusiastic, perhaps excessively so, but then subsequently overreact in the opposite direction, abandoning them when the first bumps in the road come along.
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Structural domains in RNAi [PDF]
FEBS Letters, 2005 Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double‐stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two ...
Robert E. Collins, Xiaodong Cheng
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Antiviral Applications of RNAi [PDF]
, 2006 RNA interference is a natural mechanism by which small interfering (si)RNA operates to specifically and potently down-regulate the expression of a target gene. This down-regulation has been thought to predominantly function at the level of the messenger (m)RNA, post-transcriptional gene silencing (PTGS). Recently, the discovery that siRNAs can function
John J. Rossi, Kevin V. Morris
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MicroRNAs that interfere with RNAi [PDF]
Worm, 2013 A recent study by Massirer et al. in the nematode C. elegans has shown that a family of microRNAs (miRNAs), miR-35-41, regulates the efficiency of RNA interference (RNAi), revealing a new connection between these small RNA pathways. In this commentary, we discuss the potential mechanisms for cross regulation in the miRNA and RNAi pathways and the ...
Katlin B. Massirer, Amy E. Pasquinelli
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GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.
Nucleic Acid Therapeutics, 2018 Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease.
Aaron D. Springer, S. Dowdy
semanticscholar +1 more source