Results 51 to 60 of about 267,874 (284)

Quantitative Proteomics Identifies Metabolic Pathways Affected by Babesia Infection and Blood Feeding in the Sialoproteome of the Vector Rhipicephalus bursa

Vaccines, 2020
The negative impact of ticks and tick-borne diseases on animals and human health is driving research to discover novel targets affecting both vectors and pathogens.
Joana Couto, Margarita Villar, Lourdes Mateos-Hernández, Joana Ferrolho, Gustavo S. Sanches, Ana Sofia Santos, Maria Margarida Santos-Silva, João Nobre, Olga Moreira, Sandra Antunes, José de la Fuente, Ana Domingos   +11 more
doaj   +1 more source

Effects of pH on Double Stranded RNA Stability in European Corn Borer Nucleases [PDF]

, 2019
RNA interference (RNAI) is an immune response that can be exploited to make greener pesticides. It works by inciting suppression of a specific target gene using fed or injected dsRNA.
Biondi, Marie, Cooper, Anastasia, Song, Huifang, Yu, Zhitao, Zhu, Kun Yan   +4 more
core  

The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]

, 2010
The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Antony P. Page, Bernard, Blaxter, Chu, Cook, Fessler, Ford, Frand, Ghedin, Gillian McCormack, Gillian Stepek, Hawdon, Johnstone, Johnstone, Kingston, Kingston, Kramerova, Kramerova, Kress, Mieszczanek, Milstone, Nagano, Novelli, Novelli, Paesen, Page, Page, Poole, Priess, Redmond, Rhoads, Sasaki, Scott, Shamansky, Skuce, Stanssens, Studier, Thacker, Thacker, Thacker, Thacker, Thein, Wells, Winter   +43 more
core   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits

G3: Genes, Genomes, Genetics, 2019
Physiology, fitness and disease phenotypes are complex traits exhibiting continuous variation in natural populations. To understand complex trait gene functions transgenic lines of undefined genetic background are often combined to assess quantitative ...
Amalia Evangelou, Anastasia Ignatiou, Chloi Antoniou, Sofia Kalanidou, Sotiroula Chatzimatthaiou, Gavriella Shianiou, Soteroulla Ellina, Rafaella Athanasiou, Myrofora Panagi, Yiorgos Apidianakis, Chrysoula Pitsouli   +10 more
doaj   +1 more source

Gold Nanoparticles in Conjunction with Nucleic Acids as a Modern Molecular System for Cellular Delivery

Molecules, 2020
Development of nanotechnology has become prominent in many fields, such as medicine, electronics, production of materials, and modern drugs. Nanomaterials and nanoparticles have gained recognition owing to the unique biochemical and physical properties ...
Anna Graczyk, Roza Pawlowska, Dominika Jedrzejczyk, Arkadiusz Chworos   +3 more
doaj   +1 more source

Parasite motility is critical for virulence of African trypanosomes. [PDF]

, 2018
African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie, Hill, Kent L, Kisalu, Neville, Ozcan, Aydogan, Ray, Sunayan S, Shimogawa, Michelle M, Zhang, Yibo   +6 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Speeding up RNAi [PDF]

Nature Methods, 2011
A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.
openaire   +2 more sources

Assessment of RNAi-induced silencing in banana (Musa spp.) [PDF]

, 2015
In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements.
Cammue, B.P.A., Coninck, B. de, Dang Thi Tuong Vi, Henry, I., Remy, S., Swennen, Rony L., Windelinckx, S.   +6 more
core   +1 more source