Results 61 to 70 of about 267,874 (284)
Advanced Science, EarlyView.Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu +15 more
wiley +1 more source
In silico analyses of miRNAs that Target Odorant Binding and Chemosensory Proteins in Bemisia tabaci
Turkish Journal of Agriculture: Food Science and TechnologyThe whitefly, Bemisia tabaci, damages various crops by releasing honeydew and spreading. Although farmers and pest control experts primarily rely on insecticides to manage whiteflies, the notable issue is their tendency to develop resistance to major ...
Mehtap Bal, Sevgi Maraklı
doaj +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
doaj +1 more source
The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica [PDF]
Open Biology, 2016 The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell ...
Paula Irles +2 more
doaj +1 more source
Science, 2015 RNAi therapeutics are emerging as a major drug discovery ...
Dirk Haussecker, Mark A. Kay
openaire +1 more source
secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]
, 2019 Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J. +6 more
core +2 more sources
Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly
Advanced Science, EarlyView.Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao +5 more
wiley +1 more source
Biologia Plantarum, 2019 Sri Lankan cassava mosaic virus (SLCMV) is the principal causal agent of cassava mosaic disease in the Indian subcontinent. To gain resistance against the virus, the coat protein (CP) gene, namely the AV1 of SLCMV-Adivaram isolate, was cloned in either ...
A. GOGOI +4 more
doaj +1 more source
RNA Biology, 2022 PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to protect genome integrity.
Astrid D. Haase
doaj +1 more source