Results 61 to 70 of about 323,847 (388)

An efficient deep learning based predictor for identifying miRNA-triggered phasiRNA loci in plant

Mathematical Biosciences and Engineering, 2023
Phasic small interfering RNAs are plant secondary small interference RNAs that typically generated by the convergence of miRNAs and polyadenylated mRNAs.
Yuanyuan Bu, Jia Zheng , Cangzhi Jia
doaj   +1 more source

Parasite motility is critical for virulence of African trypanosomes. [PDF]

, 2018
African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie, Hill, Kent L, Kisalu, Neville, Ozcan, Aydogan, Ray, Sunayan S, Shimogawa, Michelle M, Zhang, Yibo   +6 more
core   +1 more source

Quantitative Proteomics Identifies Metabolic Pathways Affected by Babesia Infection and Blood Feeding in the Sialoproteome of the Vector Rhipicephalus bursa

Vaccines, 2020
The negative impact of ticks and tick-borne diseases on animals and human health is driving research to discover novel targets affecting both vectors and pathogens.
Joana Couto, Margarita Villar, Lourdes Mateos-Hernández, Joana Ferrolho, Gustavo S. Sanches, Ana Sofia Santos, Maria Margarida Santos-Silva, João Nobre, Olga Moreira, Sandra Antunes, José de la Fuente, Ana Domingos   +11 more
doaj   +1 more source

RNAi Mechanisms and Applications

BioTechniques, 2008
Within the past two decades we have become increasingly aware of the roles that RNAs play in regulation of gene expression. The RNA world was given a booster shot with the discovery of RNA interference (RNAi), a compendium of mechanisms involving small RNAs (less than 30 bases long) that regulate the expression of genes in a variety of eukaryotic ...
John J. Rossi, Daniel H. Kim
openaire   +3 more sources

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. [PDF]

, 2015
The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised
Abdou, Al-Anzi, Antonello, Athippozhy, Avila, Bajgar, Barnes, Biteau, Biteau, Bontonou, Buchon, Busson, Carey, Carvalho, Casirola, Cerf, Charles, Choi, Cognigni, David, Economos, Fahrbach, Flatt, Flatt, Flatt, Glinoer, Gore, Gwinn, Hammond, Hansen, Hildebrandt, Horton, Jiang, Jindra, Jindra, Jowett, Keller, Klepsatel, Koren, Koyama, Kubli, Kunte, Langevin, Lee, Lemaitre, Li, Lodhi, Marianes, Marois, McGuire, Micchelli, Middleton, Min, Mirth, Mirth, Moshitzky, Navare, Nijhout, O'Brien, Padmanabha, Palm, Parker, Parra-Peralbo, Phillips, Piersma, R Development Core Team, Rauschenbach, Rera, Riddiford, Roa, Rogina, Ryu, Sarraf-Zadeh, Schneider, Seegmiller, Shimano, Shin, Sieber, Siegmund, Song, Speakman, Theopold, Tiu, Ueyama, Venables, Wen, Wigby, Wyatt, Yamamoto, Yin, Zhang   +90 more
core   +2 more sources

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans [PDF]

, 2011
Despite the importance of microRNAs (miRNAs) in gene regulation, it is unclear how the miRNA-Argonaute complex-or miRNA-induced silencing complex (miRISC)-can regulate the translation of their targets in such diverse ways.
Bajan, Sarah, Banville, Isabelle H., Bouasker, Samir, Giguère, Nellie J., Hutvagner, Gyorgy, Jannot, Guillaume, Piquet, Sandra, Simard, Martin J.   +7 more
core   +3 more sources

Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery

Advances in Materials, 2019
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference (RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical space.
Byungji Kim, Ji-Ho Park, M. Sailor
semanticscholar   +1 more source

Improving RNAi efficiency for pest control in crop species

BioTechniques, 2020
The application of RNAi promotes the development of novel approaches toward plant protection in a sustainable way. Genetically modified crops expressing dsRNA have been developed as commercial products with great potential in insect pest management ...
Shuo Yan, Binyuan Ren, Bo Zeng, Jie Shen
semanticscholar   +1 more source

Limitations in harnessing oral RNA interference as an antiviral strategy in Aedes aegypti

iScience
Summary: Mosquitoes, particularly Aedes aegypti, are critical vectors for globally significant pathogenic viruses. This study examines the limitations of oral RNA interference (RNAi) as a strategy to disrupt viral transmission by Ae. aegypti.
Ottavia Romoli, Annabelle Henrion-Lacritick, Hervé Blanc, Lionel Frangeul, Maria-Carla Saleh   +4 more
doaj   +1 more source

Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth

Biomolecules, 2020
Cutaneous melanoma is the most aggressive skin cancer with notorious drug resistance. Inhibition of immune checkpoint molecules is one of the most promising approaches for cancer therapy.
Ehexige Ehexige, Mingming Bao, Purevbat Bazarjav, Xiang Yu, Hai Xiao, Shuqin Han, Huricha Baigude   +6 more
doaj   +1 more source