Results 1 to 10 of about 2,156,375 (387)

Hsa_circ_0066523 promotes the proliferation and osteogenic differentiation of bone mesenchymal stem cells by repressing PTEN

Bone & Joint Research, 2021
Aims: Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box
Wei Xin, Shuai Yuan, Bo Wang, Qirong Qian, Yi Chen   +4 more
doaj   +1 more source

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Bone & Joint Research, 2023
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li   +9 more
doaj   +1 more source

LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis

Bone & Joint Research, 2023
Aims: Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore
Zhihui Li
doaj   +1 more source

Forecasting Staphylococcus aureus Infections Using Genome-Wide Association Studies, Machine Learning, and Transcriptomic Approaches

mSystems, 2022
Staphylococcus aureus is a major human and animal pathogen, colonizing diverse ecological niches within its hosts. Predicting whether an isolate will infect a specific host and its subsequent clinical fate remains unknown.
Mohamed Sassi, Julie Bronsard, Gaetan Pascreau, Mathieu Emily, Pierre-Yves Donnio, Matthieu Revest, Brice Felden, Thierry Wirth, Yoann Augagneur   +8 more
doaj   +1 more source

Gene regulation by long non-coding RNAs and its biological functions

Nature reviews. Molecular cell biology, 2020
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello, Chun-Jie Guo, Ling-Ling Chen, Maite Huarte   +3 more
semanticscholar   +1 more source

Small RNA Profile in Moso Bamboo Root and Leaf Obtained by High Definition Adapters [PDF]

, 2014
Moso bamboo (Phyllostachy heterocycla cv. pubescens L.) is an economically important fast-growing tree. In order to gain better understanding of gene expression regulation in this important species we used next generation sequencing to profile small RNAs
A Kozomara, A Mortazavi, AC Mallory, AC Mallory, AD Jayaprakash, AK Goyal, AM Gustafson, AS Zanca, B Liu, B Wang, B Zhao, Biao Ding, C Lu, C Schommer, C-Y He, E Allen, G Szittya, H Zhao, H-S Guo, Hansheng Zhao, I Mohorianu, Irina Mohorianu, J-W Wang, JF Palatnik, JH Kim, K Kruszka, K Nikovics, K Prüfer, K Sorefan, L Gutierrez, L Wu, Li Yang, M Hafner, M Javelle, M Kang, M Yoshikawa, MB Stocks, MJ Axtell, ML Gifford, MM Alonso-Peral, O Borsani, P Zhelyazkova, Ping Xu, R Schwab, R Sunkar, R Sunkar, RE Rodriguez, S Lu, S Moxon, T Li, Tamas Dalmay, V Pantaleo, X Zhang, Y Meng, Y-J Zhang, Z Peng, Z Xu, Zhimin Gao   +57 more
core   +7 more sources

Expanding the Staphylococcus aureus SarA Regulon to Small RNAs

mSystems, 2021
SarA, a transcriptional regulator of Staphylococcus aureus, is a major global regulatory system that coordinates the expression of target genes involved in its pathogenicity.
Charlotte Oriol, Liviu Cengher, Adhar C. Manna, Tony Mauro, Marie-Laure Pinel-Marie, Brice Felden, Ambrose Cheung, Astrid Rouillon   +7 more
doaj   +3 more sources

Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage

Open Life Sciences, 2021
This study aimed to investigate the molecular mechanism under the pathophysiology of subarachnoid hemorrhage (SAH) and identify the potential biomarkers for predicting the risk of SAH.
Weng Yifei
doaj   +1 more source

BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR

Bone & Joint Research, 2021
Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu, ZiHao Li, Siwen Chen, Haowen Cui, Xiang Li, Guo Dai, Fangling Zhong, Wenjun Hao, Kuibo Zhang, Hui Liu   +9 more
doaj   +1 more source

Integrating genome-wide association study with regulatory SNP annotations identified novel candidate genes for osteoporosis

Bone & Joint Research, 2023
Aims: Osteoporosis (OP) is a metabolic bone disease, characterized by a decrease in bone mineral density (BMD). However, the research of regulatory variants has been limited for BMD.
Yumeng Jia, Xin Qi, Mei Ma, Shiqiang Cheng, Bolun Cheng, Chujun Liang, Xiong Guo, Feng Zhang   +7 more
doaj   +1 more source