Results 1 to 10 of about 1,043,746 (362)
LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis
Bone & Joint Research, 2023 Aims: Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore
Zhihui Li
doaj +1 more source
Bone & Joint Research, 2021 Aims: Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box
Wei Xin +4 more
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Bone & Joint Research, 2023 Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo +9 more
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Expanding the Staphylococcus aureus SarA Regulon to Small RNAs
mSystems, 2021 SarA, a transcriptional regulator of Staphylococcus aureus, is a major global regulatory system that coordinates the expression of target genes involved in its pathogenicity.
Charlotte Oriol +7 more
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Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles [PDF]
ACS Nano, 2014 Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells.
Vineet N. KewalRamani +11 more
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BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR
Bone & Joint Research, 2021 Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu +9 more
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Combinatorics of RNA–RNA interaction [PDF]
Journal of Mathematical Biology, 2011 RNA-RNA binding is an important phenomenon observed for many classes of non-coding RNAs and plays a crucial role in a number of regulatory processes. Recently several MFE folding algorithms for predicting the joint structure of two interacting RNA molecules have been proposed.
Li, Thomas J X, Reidys, Christian
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Bone & Joint Research, 2023 Aims: Osteoporosis (OP) is a metabolic bone disease, characterized by a decrease in bone mineral density (BMD). However, the research of regulatory variants has been limited for BMD.
Yumeng Jia +7 more
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RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Michael F. Jantsch +9 more
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RNA helicases in RNA decay [PDF]
Biochemical Society Transactions, 2018 RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
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