Results 11 to 20 of about 2,156,375 (387)
RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Rajkowitsch, Lukas +9 more
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Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles [PDF]
ACS Nano, 2014 Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells.
Afonin, Kirill A. +10 more
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Combinatorics of RNA–RNA interaction [PDF]
Journal of Mathematical Biology, 2011 RNA-RNA binding is an important phenomenon observed for many classes of non-coding RNAs and plays a crucial role in a number of regulatory processes. Recently several MFE folding algorithms for predicting the joint structure of two interacting RNA molecules have been proposed.
Li, Thomas J X, Reidys, Christian
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Thermodynamics of RNA–RNA binding [PDF]
Bioinformatics, 2006 Abstract Background: Reliable prediction of RNA–RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA–mRNA binding and antisense interactions. The thermodynamics of such RNA–RNA interactions can be understood as the sum of two energy contributions: (1) the energy necessary to ‘open’ the binding site and (2) the ...
Mückstein, Ulrike +5 more
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Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future
Frontiers in Cellular and Infection Microbiology, 2021 The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s.
Guillaume Ménard +3 more
doaj +1 more source
METTL16 in human diseases: What should we do next?
Open Medicine, 2023 METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However,
Zhang Hui +4 more
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Bacterial Type I Toxins: Folding and Membrane Interactions
Toxins, 2021 Bacterial type I toxin-antitoxin systems are two-component genetic modules that encode a stable toxic protein whose ectopic overexpression can lead to growth arrest or cell death, and an unstable RNA antitoxin that inhibits toxin translation during ...
Sylvie Nonin-Lecomte +3 more
doaj +1 more source
Closing the circle : current state and perspectives of circular RNA databases [PDF]
, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority.
Vandesompele, Jo +2 more
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Toxins, 2021 The authors wish to make the following corrections to their paper [...]
Sylvie Nonin-Lecomte +3 more
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A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]
, 2015 RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia +4 more
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