Results 101 to 110 of about 365,508 (294)

RNase-substrate binding sub-sites.

, 2019
Schematic representation based on the bRNaseA active-site. P0, P1 and P2 represent binding sub-sites for the phosphate groups of the RNA substrate backbone, while B1 and B2 correspond to nucleotide base sub-sites.
Khushboo Bafna (531726), Nicolas Doucet (111644), S. Chakra Chennubhotla (5487392), Chitra Narayanan (2036602), Pratul K. Agarwal (198133)   +4 more
core   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Leveraging RIBOTAC technology: Fluorescent RNase L probes for live-cell imaging and function analysis

Heliyon
RNA-targeting small molecules, particularly RIBOnuclease TArgeting Chimeras (RIBOTACs), represent a powerful and promising therapeutic approach by selectively degrading RNAs through ribonuclease (RNase) recruitment.
Elias Khaskia, Raphael I. Benhamou
doaj   +1 more source

Semisynthesis of Ribonuclease A using Intein-Mediated Protein Ligation

The Scientific World Journal, 2002
The introduction of non-natural amino acid residues or modules into proteins provides a new means to explore the basis for conformational stability, folding/unfolding behavior, or biological function.
Ulrich Arnold, Matthew P. Hinderaker, Ronald T. Raines   +2 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

PRRSV Nsp11 antagonizes host antiviral immune response by reducing OAS1 and RNase L expressions

BMC Veterinary Research
Background Porcine reproductive and respiratory syndrome virus (PRRSV) is the pathogen of porcine reproductive and respiratory syndrome (PRRS) which is an important viral infectious disease.
Dandan Jiang, Xiaoran Wang, Chao Sui, Xiangju Wu, Yue Hu, Xiaoyan Cong, Juntong Li, Jing Qi, Changhee Lee, Meng Zhou, Shubo Zhao, Yijun Du   +11 more
doaj   +1 more source

Protein Interactions: the Multiple Solvent Crystal Structures of RNAse A and Analysis of the RalA and RalBP Complex

, 2009
In both structure and function, Ribonuclease A (RNAse A) and RalA are two very different proteins. RNAse A is an extracellular digestive enzyme that catalyzes the breakdown of 3’-5’ phosphodiester linkages in single stranded RNA.
Dechene, Michelle Christine
core  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Regulation of RNase PH during nutrient deprivation: the role of proteases, GroEL, and RNase II

mBio
RNase PH is a critical exoribonuclease in Escherichia coli that participates in tRNA maturation and RNA degradation. In earlier work, it was observed that levels of RNase PH decreased as much as 90% under conditions of nutrient deprivation, such as ...
Ashraf Hussain, Murray P. Deutscher
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source