Results 61 to 70 of about 476,060 (306)

The Sequential Mechanism of HIV Reverse Transcriptase RNase H [PDF]

Journal of Biological Chemistry, 2000
Synthesis of the minus strand of viral DNA by human immunodeficiency virus, type 1 (HIV-1) reverse transcriptase is accompanied by RNase H degradation of the viral RNA genome. RNA fragments remain after synthesis and are degraded by the polymerase-independent mode of RNase H cleavage.
Robert A. Bambara, Philip J. Fay, Mini Balakrishnan, Chockalingam Palaniappan, Michele Wisniewski   +4 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Protein folding in the modern era: a pedestrian's guide [PDF]

arXiv, 2020
The prediction of protein secondary and tertiary structures from the primary amino acid sequence is both an incredibly important and incredibly difficult problem. Accurate prediction of a protein's native structure can provide critical insights about its function, ultimately leading to breakthoughs in drug design and disease diagnosis.
arxiv  

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals

Viruses, 2017
The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens.
Sinaye Ngcapu, Kristof Theys, Pieter Libin, Vincent C. Marconi, Henry Sunpath, Thumbi Ndung’u, Michelle L. Gordon   +6 more
doaj   +1 more source

Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients. [PDF]

PLoS ONE, 2008
BACKGROUND: Although extensive HIV drug resistance information is available for the first 400 amino acids of its reverse transcriptase, the impact of antiretroviral treatment in C-terminal domains of Pol (thumb, connection and RNase H) is poorly ...
André F A Santos, Renan B Lengruber, Esmeralda A Soares, Abhay Jere, Eduardo Sprinz, Ana M B Martinez, Jussara Silveira, Fernando S Sion, Vinay K Pathak, Marcelo A Soares   +9 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Partitioning of a graph into induced subgraphs not containing prescribed cliques [PDF]

arXiv, 2022
Let $K_p$ be a complete graph of order $p\geq 2$. A $K_p$-free $k$-coloring of a graph $H$ is a partition of $V(H)$ into $V_1, V_2\ldots,V_k$ such that $H[V_i]$ does not contain $K_p$ for each $i\leq k $. In 1977 Borodin and Kostochka conjectured that any graph $H$ with maximum degree $\Delta(H)\geq 9$ and without $K_{\Delta(H)}$ as a subgraph has ...
arxiv  

RNase H and replication of ColE1 DNA in Escherichia coli [PDF]

Journal of Bacteriology, 1986
Amber mutations within the rnh (RNase H) gene of Escherichia coli K-12 were isolated by selecting for bacteria capable of replicating in a sup+ background replication-defective cer-6 mutant of the ColE1 replicon. The cer-6 mutation is an alteration of one base pair located 160 nucleotides upstream of the unique replication origin of this plasmid ...
S Naito, H Uchida
openaire   +3 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

On generalized list $\G$-free colorings of graphs [PDF]

arXiv, 2022
For given graph $H$ and graphical property $P$, the conditional chromatic number $\chi(H,P)$ of $H$, is the smallest number $k$, so that $V(H)$ can be decomposed into sets $V_1,V_2,\ldots, V_k$, in which $H[V_i]$ satisfies the property $P$, for each $1\leq i\leq k$.
arxiv