Results 81 to 90 of about 476,060 (306)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Self-Assembly of Arbitrary Shapes Using RNAse Enzymes: Meeting the Kolmogorov Bound with Small Scale Factor (extended abstract) [PDF]
arXiv, 2010 We consider a model of algorithmic self-assembly of geometric shapes out of square Wang tiles studied in SODA 2010, in which there are two types of tiles (e.g., constructed out of DNA and RNA material) and one operation that destroys all tiles of a particular type (e.g., an RNAse enzyme destroys all RNA tiles).
arxiv
Extremal results on $G$-free colorings of graphs [PDF]
arXiv, 2022 Let $H=(V(H),E(H))$ be a graph. A $k$-coloring of $H$ is a mapping $\pi : V(H) \longrightarrow \{1,2,\ldots, k\}$ so that each color class induces a $K_2$-free subgraph. For a graph $G$ of order at least $2$, a $G$-free $k$-coloring of $H$ is a mapping $\pi : V(H) \longrightarrow \{1,2,\ldots,k\}$ so that the subgraph of $H$ induced by each color class
arxiv
Molecular Therapy: Nucleic Acids, 2017 Antisense oligonucleotides (ASOs) have the potential to discriminate between subtle RNA mismatches such as SNPs. Certain mismatches, however, allow ASOs to bind at physiological conditions and result in RNA cleavage mediated by RNase H.
Michael E. Østergaard +6 more
doaj +1 more source
One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts
Molecules, 2020 There is an increasing demand for efficient and robust production of short RNA molecules in both pharmaceutics and research. A standard method is in vitro transcription by T7 RNA polymerase.
Hannes Feyrer +3 more
doaj +1 more source
A Computational Model for Predicting RNase H Domain of Retrovirus
PLOS ONE, 2016 RNase H (RNH) is a pivotal domain in retrovirus to cleave the DNA-RNA hybrid for continuing retroviral replication. The crucial role indicates that RNH is a promising drug target for therapeutic intervention. However, annotated RNHs in UniProtKB database have still been insufficient for a good understanding of their statistical characteristics so far ...
Sijia Wu, Xinman Zhang, Jiuqiang Han
openaire +5 more sources
Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification
FEBS Open Bio, EarlyView.Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
The covering threshold of a directed acyclic graph by directed acyclic subgraphs [PDF]
arXiv, 2022 Let $H$ be a directed acyclic graph other than a rooted star. It is known that there are constants $c(H)$ and $C(H)$ such that the following holds for the complete directed graph $D_n$. There are at most $C\log n$ directed acyclic subgraphs of $D_n$ that cover every $H$-copy of $D_n$, while fewer than $c\log n$ directed acyclic subgraphs of $D_n$ do ...
arxiv
MoleculesThere is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity.
Nhat Quang Tu +9 more
doaj +1 more source