Results 11 to 20 of about 3,043 (149)
Identification of RMP24 and RMP64, human ribonuclease MRP-specific protein components [PDF]
Cell ReportsSummary: Human RNase MRP is a ribonucleoprotein (RNP) enzyme that processes precursor rRNA (pre-rRNA) at ITS1 site 2 and may have additional activities. It is an endonuclease related to RNase P, which processes pre-tRNAs and pre-tRNA-like substrates.
Rui Che +5 more
doaj +2 more sources
Of proteins and RNA: The RNase P/MRP family [PDF]
RNA, 2010 Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of only two known RNA-based enzymes found in all three domains of life. The RNA component is the catalytic moiety of RNases P across all phylogenetic domains; it contains a well-conserved core, whereas peripheral structural elements are diverse.
Olga Esakova, Andrey S. Krasilnikov
openalex +3 more sources
Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP. [PDF]
Cell, 2016 Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP,
Lemieux B +6 more
europepmc +4 more sources
PLoS ONE, 2012 RNA biogenesis, including biosynthesis and maturation of rRNA, tRNA and mRNA, is a fundamental process that is critical for cell growth, division and differentiation.
Si-Qi Wang +4 more
doaj +3 more sources
Conserved and variable domains of RNase MRP RNA [PDF]
RNA Biology, 2009 Ribonuclease MRP is a eukaryotic ribonucleoprotein complex consisting of one RNA molecule and 7-10 protein subunits. One important function of MRP is to catalyze an endonucleolytic cleavage during processing of rRNA precursors. RNase MRP is evolutionary related to RNase P which is critical for tRNA processing.
Marcela Dávila López +2 more
openalex +3 more sources
Differential association of protein subunits with the human RNase MRP and RNase P complexes [PDF]
RNA, 2006 RNase MRP is a eukaryotic endoribonuclease involved in nucleolar and mitochondrial RNA processing events. RNase MRP is a ribonucleoprotein particle, which is structurally related to RNase P, an endoribonuclease involved in pre-tRNA processing. Most of the protein components of RNase MRP have been reported to be associated with RNase P as well.
Tim J. M. Welting +3 more
openalex +4 more sources
RNA–protein interactions in the human RNase MRP ribonucleoprotein complex [PDF]
RNA, 1999 The eukaryotic nucleolus contains a large number of small RNA molecules that, in the form of small nucleolar ribonucleoprotein complexes (snoRNPs), are involved in the processing and modification of pre-rRNA. One of the snoRNPs that has been shown to possess enzymatic activity is the RNase MRP. RNase MRP is an endoribonuclease involved in the formation
Helma Pluk +4 more
openalex +4 more sources
Molecular determinants of RNase MRP specificity and function
AbstractRNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a unique subunit, Rpp21, whereas no RNase MRP-specific proteins have been found in humans, limiting ...
Eric M. Smith +3 more
openalex +3 more sources
A Novel Model for the RNase MRP-Induced Switch between the Formation of Different Forms of 5.8S rRNA. [PDF]
Int J Mol Sci, 2021 Li X, Zengel JM, Lindahl L.
europepmc +3 more sources
Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease. [PDF]
Cell Mol Life Sci, 2011 RNase MRP is a conserved endoribonuclease, in humans consisting of a 267-nucleotide RNA associated with 7-10 proteins. Mutations in its RNA component lead to several autosomal recessive skeletal dysplasias, including cartilage-hair hypoplasia (CHH).
Mattijssen S +6 more
europepmc +6 more sources