Results 21 to 30 of about 195 (84)

Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1

open access: yesPlant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.
ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek   +5 more
wiley   +1 more source

Folate‐Associated Gene Expression in Primary Tumors Is Associated With Tumor Response and Progression‐Free Survival of Patients With Metastatic Colorectal Cancer Undergoing 5‐FU/Leucovorin‐Based Combination Chemotherapy

open access: yesCancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background 5‐Fluorouracil (5‐FU) and the Folate Leucovorin (LV) form the chemotherapy backbone for metastatic colorectal cancer (mCRC). Tumoral expression of specific folate‐associated genes is associated with the risk of recurrence in stage III CRC following adjuvant 5‐FU/LV (FLV)‐based combination chemotherapy according to the Nordic bolus ...
Elisabeth Odin   +7 more
wiley   +1 more source

RNA‐seq analysis of mitochondria‐related genes regulated by AMPK in the human trophoblast cell line BeWo

open access: yesAnimal Models and Experimental Medicine, Volume 8, Issue 4, Page 649-661, April 2025.
Using RNA‐seq and other bioinformatics analyses, three clusters of mitochondria related genes, including aldo‐keto reductase family 1 members B10 and B15 (AKR1B10, AKR1B15), alanyl‐tRNA synthetase 1 (AARS1), mitochondrial ribosomal protein S6 (MRPS6), mitochondrial calcium uniporter dominant negative subunit beta (MCUB) and dihydrolipoamide branched ...
Bin Wu   +6 more
wiley   +1 more source

Thermally Triggered Double Emulsion‐Integrated Hydrogel Microparticles for Multiplexed Molecular Diagnostics

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
This paper presents the development of a multiplexed RT‐qPCR using a double emulsion (DE)‐based carrier and hydrogel microparticle reactor, termed TaqPIN. The DE, enhanced by a hydrogel network, securely stores nucleic acid reagents until heating releases them for reaction.
Eui Ju Jeon   +14 more
wiley   +1 more source

Regulation of Shade Avoidance Under Low‐Blue‐Light by MTA in Soybean

open access: yesAdvanced Science, Volume 12, Issue 5, February 3, 2025.
This study explores the role of N6‐methyladenosine (m6A) in shade avoidance in soybean. By generating double mutants impaired in m6A writer genes, researchers found that m6A regulates shade avoidance response and shade resistance by altering the expression of blue light signaling genes, offering insights into plant adaptation to changing light ...
Liya Zhang   +10 more
wiley   +1 more source

A Comprehensive Transcriptome Atlas Reveals the Crucial Role of LncRNAs in Maintaining Nodulation Homeostasis in Soybean

open access: yesAdvanced Science, Volume 12, Issue 7, February 17, 2025.
Symbiotic nitrogen fixation promotes soybean growth, but maintaining energy balance is challenging. RNA‐seq of three organs of inoculated soybean identifies 88,814 mRNAs and 6,156 ncRNAs. Roots exhibit the most NR‐ncRNAs and dynamic crosstalk controlled by GmNARK.
Yanru Lin   +6 more
wiley   +1 more source

A Seascape Genomics Perspective on Restrictive Genetic Connectivity Overcoming Signals of Local Adaptations in the Green Abalone (Haliotis fulgens) of the California Current System

open access: yesEcology and Evolution, Volume 15, Issue 2, February 2025.
The green abalone exhibits a distinctive neutral genetic structuring influenced by geographic distance and marine currents rather than local adaptations. Analyses using 1900 neutral and 17 putative outlier SNPs revealed three distinct populations: the North group (California to Ensenada, Baja California), a population on Guadalupe Island, and the South
Jorge Alberto Mares‐Mayagoitia   +12 more
wiley   +1 more source

Comparison of Methods for Isolation and Characterization of Total and Astrocyte‐Enriched Extracellular Vesicles From Human Serum and Plasma

open access: yesJournal of Extracellular Biology, Volume 4, Issue 2, February 2025.
Experimental workflow for total EV isolation and AEEV enrichment. A. Human serum or plasma samples were collected from blood and stored at −80°C until isolation of total EV. B. Depiction of several methods that were used to isolate TEV, which can be stored in researcher's desired buffer. C.
Leandra K. Figueroa‐Hall   +10 more
wiley   +1 more source

Circular RNAs in cancer

open access: yesMedComm, Volume 6, Issue 2, February 2025.
Circular RNAs (circRNAs) play essential roles in hallmarks of cancer, exerting either oncogenic or tumor‐suppressive effects, as observed in thyroid cancer. This review presents an extensive review of circRNAs, encompassing their biogenesis, characteristics, functions, and mechanisms of turnover.
Yang Guo   +8 more
wiley   +1 more source

Circular RNA regulatory role in pathological cardiac remodelling

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 2, Page 316-339, January 2025.
Abstract Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting in progressive loss of heart function and ultimately leading to heart failure. Circular RNAs (circRNAs) are a recently rediscovered class of non‐coding RNAs that play regulatory roles in the pathogenesis of cardiovascular diseases ...
Alessia Bibi   +15 more
wiley   +1 more source

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