Results 31 to 40 of about 195 (84)

X and Y Differences in Melanoma Survival Between the Sexes

Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.
Role of X and Y gene expression in the improved survival of females from cancer. Created with BioRender.com. ABSTRACT Marked differences in survival from melanoma are noted between men and women that cannot be accounted for by behavioral differences. We and others have provided evidence that this difference may be due to increased expression of immune ...
Peter Hersey, Hsin‐Yi Tseng, Sara Alavi, Jessamy Tiffen   +3 more
wiley   +1 more source

MicroRNA750-3p Targets Processing of Precursor 7 to Suppress Rice Black-Streaked Dwarf Virus Propagation in Vector Laodelphax striatellus

Viruses
MicroRNAs (miRNAs) are non-coding RNAs, which, as members of the RNA interference pathway, play a pivotal role in antiviral infection. Almost 80% of plant viruses are transmitted by insect vectors; however, little is known about the interaction of the ...
Haitao Wang, Yan Dong, Qiufang Xu, Man Wang, Shuo Li, Yinghua Ji   +5 more
doaj   +1 more source

Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation

IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.
Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou, Chrysostomos Avgeros, Maria Konstantinidou, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

miRNA interplay: Mechanisms and therapeutic interventions in cancer

MedComm – Oncology, Volume 3, Issue 4, December 2024.
By integrating RNA sequencing, CRISPR, bioinformatics, and computational models, we have deepened understanding of MicroRNA (miRNA) interactions. miRNAs regulated by ceRNAs are closely linked to cancer development. They are detectable in various samples and serve as biomarkers for cancer diagnosis, prognosis, and prediction.
Zehua Wang, Hangxuan Wang, Shuhan Zhou, Jiasheng Mao, Zhiqing Zhan, Shiwei Duan   +5 more
wiley   +1 more source

Tumor‐Resident Microbiota‐Based Risk Model Predicts Neoadjuvant Therapy Response of Locally Advanced Esophageal Squamous Cell Carcinoma Patients

Advanced Science, Volume 11, Issue 41, November 6, 2024.
The microbiota‐based risk prediction (MRP) model and the integrated MRP‐plus model, incorporating MRP, tumor stage, and tumor size, are devised to discern patients suitable for neoadjuvant therapy (NAT) and prognostic outcomes for those with ESCC. Both the MRP and MRP‐plus models can be practical and reliable tools for guiding treatment strategies in ...
Hong Wu, Qianshi Liu, Jingpei Li, Xuefeng Leng, Yazhou He, Yiqiang Liu, Xia Zhang, Yujie Ouyang, Yang Liu, Wenhua Liang, Chuan Xu   +10 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Engineered Lipids for Intracellular Reactive Oxygen Species Scavenging in Steatotic Hepatocytes

Small, Volume 20, Issue 44, November 1, 2024.
The level of intracellular reactive oxygen species (ROS) in steatotic cells is lowered by delivering tailored phospholipids to lipid droplets via intrinsic intracellular transport mechanisms. Fluorescent lipids and a EUK salen–manganese derivative conjugated to lipids, both formulated as liposomes, effectively target intracellular lipid droplets in ...
Isabella N. Westensee, Paula de Dios Andres, Edit Brodszkij, Pierre‐Louis Descours, Diego Perez‐Rodriguez, Antonella Spinazzola, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +1 more source

Mitochondrial ribosome biogenesis and redox sensing

FEBS Open Bio, Volume 14, Issue 10, Page 1640-1655, October 2024.
Mitoribosome assembly coordinates rRNAs folding and modification with riboprotein incorporation assisted by assembly factors like RNA helicases, GTPases, and RNA‐modifying enzymes. Biochemical and structural analyses have enhanced the pathway resolution.
Michele Brischigliaro, Ana Sierra‐Magro, Ahram Ahn, Antoni Barrientos   +3 more
wiley   +1 more source

IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

Thoracic Cancer, Volume 15, Issue 29, Page 2116-2127, October 2024.
Our investigation revealed that activation of IRE1α‐XBP1 pathway leads to an increase in MDR‐related protein 1 (MRP1) expression, which facilitates drug extrusion and confers resistance to cytotoxic chemotherapy. At the molecular level, SREBP1 directly controls the transcription of MRP1 by binding to its promoter, and its expression is dependent on ...
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu   +9 more
wiley   +1 more source

Mitochondrial DNA replication is essential for neurogenesis but not gliogenesis in fetal neural stem cells

Development, Growth &Differentiation, Volume 66, Issue 8, Page 398-413, October 2024.
We show that neural stem cells (NSCs) dramatically increase their mtDNA content during differentiation. Short‐term inhibition of mtDNA replication and subsequent reduction of mtDNA content led to specific reduction in neurogenesis, whereas gliogenesis was not affected. These effects were associated with neither alterations in energy content nor changes
Meri Walter‐Manucharyan, Melanie Martin, Julia Pfützner, Franz Markert, Gerhard Rödel, Andreas Deussen, Andreas Hermann, Alexander Storch   +7 more
wiley   +1 more source