Results 51 to 60 of about 3,043 (149)

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Scientific Reports, 2017
Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development.
Mandy M. F. Steinbusch, Marjolein M. J. Caron, Don A. M. Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J. M. Pruijn, Wouter Verhesen, Blanche L. M. Schroen, Lodewijk W. van Rhijn, Bernhard Zabel, Tim J. M. Welting   +10 more
doaj   +1 more source

A nuclear function for RNase MRP. [PDF]

Proceedings of the National Academy of Sciences, 1994
The site-specific endoribonuclease RNase MRP was first identified 7 years ago as an RNA-processing activity in mammalian cells (1, 2). In the original description of this ribonucleoprotein, as isolated from either mouse or human cells, it was shown that the enzyme had the capacity to cleave RNA in a sequence-specific manner that matched one of the ...
openaire   +2 more sources

A method for rapid similarity analysis of RNA secondary structures

BMC Bioinformatics, 2006
Background Owing to the rapid expansion of RNA structure databases in recent years, efficient methods for structure comparison are in demand for function prediction and evolutionary analysis.
Liu Na, Wang Tianming
doaj   +1 more source

Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei

Malaria Journal, 2009
Background The ATP-binding cassette (ABC) superfamily is one of the largest evolutionarily conserved families of proteins. ABC proteins play key roles in cellular detoxification of endobiotics and xenobiotics.
González-Méndez Ricardo, Szeto Ada C, González-Pons María, Serrano Adelfa E   +3 more
doaj   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Homology-based annotation of non-coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum

BMC Genomics, 2009
Background Schistosomes are trematode parasites of the phylum Platyhelminthes. They are considered the most important of the human helminth parasites in terms of morbidity and mortality.
Santana Clara, Brindley Paul J, Hertel Jana, Rose Dominic, Marz Manja, Copeland Claudia C, Kehr Stephanie, Attolini Camille, Stadler Peter F   +8 more
doaj   +1 more source

Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25 [PDF]

RNA, 2006
Rpp20 and Rpp25 are subunits of the human RNase MRP and RNase P endoribonucleases belonging to the Alba superfamily of nucleic acid binding proteins. These proteins, which bind very strongly to each other, transiently associate with RNase MRP. Here, we show that the Rpp20-Rpp25 heterodimer is resistant to both high concentrations of salt and a nonionic
Welting, T.J.M., Peters, F.M.A., Hensen, S.M.M., Doorn, N.L. van, Kikkert, B.J., Raats, J.M.H., Venrooij, W.J.W. van, Pruijn, G.J.M.   +7 more
openaire   +3 more sources

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 12, Issue 30, August 14, 2025.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Skeletal Muscle Mitochondria Contain Nuclear‐Encoded RNA Species Prior to and Following Adaptation to Exercise Training in Rats

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Here, we report that mitochondria from rat skeletal muscle contain a select population of nuclear‐encoded protein‐coding and noncoding RNAs, including 3 microRNAs whose expression tended to be altered by exercise training. These findings suggest that mitochondria‐localized nuclear‐encoded RNAs may play a role in mediating the beneficial adaptive ...
Jessica L. Silver, Séverine Lamon, Stella Loke, Gisella Mazzarino, Larry Croft, Mark Ziemann, Megan Soria, Glenn D. Wadley, Adam J. Trewin   +8 more
wiley   +1 more source