Broadening the phenotypic spectrum of POP1-skeletal dysplasias: identification of POP1 mutations in a mild and severe skeletal dysplasia. [PDF]
POP1 is a large protein common to the RNase-MRP and RNase-P (RMRP) endoribonucleoprotein complexes. Although its precise function is unknown, it appears to participate in the assembly or stability of both complexes.
Bonafé+40 more
core +3 more sources
RNase MRP/RNase P: a structure‐function relation conserved in evolution? [PDF]
RNase P and RNase MRP are related ribonucleoproteins. RNase MRP processes mitochondrial precursor‐ (primer) RNAs, whereas RNase P cleaves precursor‐tRNAs to produce their mature 5'‐ends. Both RNase P and RNase MRP are associated with the Th/To ribonucleoprotein suggesting possible interrelated pathways and/or functions.
openaire +3 more sources
RNA–protein interactions in the human RNase MRP ribonucleoprotein complex [PDF]
The eukaryotic nucleolus contains a large number of small RNA molecules that, in the form of small nucleolar ribonucleoprotein complexes (snoRNPs), are involved in the processing and modification of pre-rRNA. One of the snoRNPs that has been shown to possess enzymatic activity is the RNase MRP. RNase MRP is an endoribonuclease involved in the formation
Pluk, W.L.L.P.+4 more
openaire +4 more sources
Imaging of RNase Mitochondrial RNA Processing Localization Using Fluorescent Microscopy [PDF]
This paper presents a method for imaging RNase mitochondrial RNA processing localization using fluorescent microscopy. RNase mitochondrial RNA Processing, MRP, is an essential ribonucleoprotein endoribonuclease that functions in the degradation of ...
Marascalchi, Bryan
core +1 more source
Difference between Mitochondrial RNase P and Nuclear RNase P [Letters to the Editor] [PDF]
[Discussion of: Puranam, R. S., and G. Attardi. 2001. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol. Cell. Biol. 21:548-561.
Attardi, Giuseppe+3 more
core
Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium [PDF]
Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs)
Abudureyimu, A+6 more
core +1 more source
PiRaNhA: A server for the computational prediction of RNA-binding residues in protein sequences [PDF]
The PiRaNhA web server is a publicly available online resource that automatically predicts the location of RNA-binding residues (RBRs) in protein sequences.
Berman+15 more
core +4 more sources
A specialized processing body that is temporally and asymmetrically regulated during the cell cycle in Saccharomyces cerevisiae [PDF]
RNase mitochondrial RNA processing (MRP) is an essential ribonucleoprotein endoribonuclease that functions in the degradation of specific mRNAs involved in cell cycle regulation.
Aulds, Jason+2 more
core +2 more sources
Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits [PDF]
Yeast Rrp5p, one of the few trans-acting proteins required for the biogenesis of both ribosomal subunits, has a remarkable two-domain structure. Its C-terminal region consists of seven tetratricopeptide motifs, several of which are crucial for cleavages ...
Faber, A.W.+4 more
core +4 more sources
Modulation of STAT3 signaling, cell redox defenses and cell cycle checkpoints by β-caryophyllene in cholangiocarcinoma cells: possible mechanisms accounting for doxorubicin chemosensitization and chemoprevention [PDF]
Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes.
Di Giacomo, Silvia+8 more
core +1 more source