Towards plant resistance to viruses using protein-only RNase P [PDF]
Nature Communications, 2021 New approaches to plant disease control are important for pathogens that are difficult to control by existing methods. Here, the authors report a potential strategy to combat plant viruses by cytosolic expressed protein-only RNase P and show its ability ...
Anthony Gobert +8 more
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Surveillance of RNase P, PMMoV, and CrAssphage in wastewater as indicators of human fecal concentration across urban sewer neighborhoods, Kentucky. [PDF]
FEMS Microbes, 2022 Wastewater surveillance has been widely used as a supplemental method to track the community infection levels of severe acute respiratory syndrome coronavirus 2. A gap exists in standardized reporting for fecal indicator concentrations, which can be used
Holm RH +9 more
europepmc +4 more sources
Engineering of RNase P Ribozymes for Therapy against Human Cytomegalovirus Infection [PDF]
VirusesNucleic acid-based gene interference and editing strategies, such as antisense oligonucleotides, ribozymes, RNA interference (RNAi), and CRISPR/Cas9 coupled with guide RNAs, are exciting research tools and show great promise for clinical applications in ...
Adam Smith +3 more
doaj +2 more sources
RNase P: Beyond Precursor tRNA Processing. [PDF]
Genomics Proteomics BioinformaticsAbstract Ribonuclease P (RNase P) was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components.
Wang P, Lin J, Zheng X, Xu X.
europepmc +3 more sources
Potential Applications of RNase P Ribozyme Against Hepatitis B Virus [PDF]
MoleculesNucleic acid-based gene-interfering molecules, such as antisense oligonucleotides, ribozymes, and small interfering RNA (siRNA), represent exciting gene-targeting agents for therapeutic applications.
Thomas Sorrell, Yujun Liu, Fenyong Liu
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The evolution of RNase P [PDF]
RNA, 2015 Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.050732.115. Freely available online through the RNA Open Access option.
Engelke, David R., Fierke, Carol A.
openaire +3 more sources
Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits. [PDF]
Nucleic Acids Res, 2023 RNase P is the endonuclease responsible for the 5’-end processing of tRNA precursors (pre-tRNAs). Unlike the single-subunit protein-only RNase P (PRORP) found in plants or protists, human mitochondrial RNase P is a multi-enzyme assembly that in addition ...
Vilardo E +4 more
europepmc +2 more sources
The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex [PDF]
mBioTo survive in harsh natural environments, translation and mRNA metabolism must be tightly and coordinately controlled, as saving biological costs increases fitness. However, the roles of protein chaperones in this control system are unclear.
Mitsuo Ogura +3 more
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RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences
Biomolecules, 2015 The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown.
Merel Derksen +2 more
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Ligand-dependent tRNA processing by a rationally designed RNase P riboswitch. [PDF]
Nucleic Acids Res, 2021 Ender A +5 more
europepmc +3 more sources