Results 41 to 50 of about 18,946,844 (347)
Silencing Antibiotic Resistance with Antisense Oligonucleotides
Biomedicines, 2021 Antisense technologies consist of the utilization of oligonucleotides or oligonucleotide analogs to interfere with undesirable biological processes, commonly through inhibition of expression of selected genes.
Saumya Jani +2 more
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PLoS ONE, 2015 Transfer RNA (tRNA) precursors undergo endoribonucleolytic processing of their 5’ and 3’ ends. 5’ cleavage of the precursor transcript is performed by ribonuclease P (RNase P).
Wenbin Zhou +5 more
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Difference between Mitochondrial RNase P and Nuclear RNase P [PDF]
Molecular and Cellular Biology, 2001 We previously demonstrated that mammalian cells contain at least two distinct RNase P activities, one nuclear and one mitochondrial (5, 7). These enzymes were shown to have different substrate specificities and distinct molecular and enzymatic properties (5–7).
Walter Rossmanith, Thomas Potuschak
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RNase P RNA‐mediated cleavage [PDF]
IUBMB Life, 2009 AbstractMetal(II)‐induced hydrolysis of RNA produce products with 5′‐hydroxyls and 2′;3′‐cyclic phosphates at the ends. Ribozymes are RNA molecules that act as catalysts. Some ribozymes that cleave RNA also generate 5′‐hydroxyls and 2′;3′‐cyclic phosphates whereas others produces 5′‐phosphates and 3′‐hydroxyls at the ends of the cleavage products ...
Leif A, Kirsebom, Stefan, Trobro
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A novel mechanism of RNase L inhibition: Theiler\u27s virus L* protein prevents 2-5A from binding to RNase L [PDF]
, 2018 The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread ...
Drappier, Melissa +8 more
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A functional RNase P protein subunit of bacterial origin in some eukaryotes [PDF]
, 2011 RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein.
Bernal Bayard, Pilar +5 more
core +1 more source
A novelHSD17B10mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression [PDF]
RNA Biology, 2016 Marni J. Falk +12 more
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Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. [PDF]
, 2017 External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Li, Wei +9 more
core +2 more sources
Nucleic Acids Research, 2020 Pentatricopeptide repeat (PPR) motifs are α-helical structures known for their modular recognition of single-stranded RNA sequences with each motif in a tandem array binding to a single nucleotide.
T. Teramoto +5 more
semanticscholar +1 more source
Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals
BMC Evolutionary Biology, 2009 Background Members of the Ribonuclease (RNase) T2 family are common models for enzymological studies, and their evolution has been well characterized in plants.
Essner Jeffrey J +5 more
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