Results 41 to 50 of about 436,820 (281)

Comparative Analysis of Ribonuclease P RNA of the Planctomycetes [PDF]

, 2004
The planctomycetes, order Planctomycetales, are a distinct phylum of domain Bacteria. Genes encoding the RNA portion of ribonuclease P (RNase P) of some planctomycete members were sequenced and compared with existing database planctomycete sequences ...
Altman, Altman, Brochier, Brown, Brown, Brown, Butler, Christian, Condon, Derakshani, Deutscher, Di Giulio, Embley, Felsenstein, Frank, Franzmann, Fuerst, Fuerst, Garrity, Giovannoni, Glöckner, Green, Guerrier-Takada, Haas, Haas, Haas, Hancock, Harris, Harris, Herrmann, Hugenholtz, Jeffares, John A. Fuerst, Kirsebom, Kuypers, Liesack, Liesack, Lindsay, Lindsay, Maeda, Margaret K. Butler, Massire, Massire, Nicholas, Oh, Pace, Pitulle, Schlesner, Schlesner, Schlesner, Schmid, Schön, Sinninghe Damsté, Strous, Vergin, Vioque, Walter, Wang, Woese, Yoon, Zahler, Zuker   +61 more
core   +1 more source

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]

, 2015
RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia, Urayama, Shiro, Wang, Wei-Peng, Yu, Ai-Ming, Zeng, Su   +4 more
core   +2 more sources

The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions

Biomolecules, 2016
Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5’ end maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes have been identified and studied throughout the three domains of life ...
Bradley P. Klemm, Nancy Wu, Yu Chen, Xin Liu, Kipchumba J. Kaitany, Michael J. Howard, Carol A. Fierke   +6 more
doaj   +1 more source

Cationic poly(amidoamine) promotes cytosolic delivery of bovine RNase A in melanoma cells, while maintaining its cellular toxicity [PDF]

, 2015
Ribonucleases are known to cleave ribonucleic acids, inducing cell death. RNase A, a member of the ribonuclease family, generally displayed poor in vitro activity. This has been attributed to factors such as low intracellular delivery.
Akinc, Almeida, Berisio, Cafaro, Chao, Cohen, Coué, Coué, De Lorenzo, Di Donato, Ding, Dubois, Ellis, Ercole, Ferruti, Foglia, Futami, Futami, Futami, Hattori, Hunter, Iversen, Ivinova, Karayianni, Larsericsdotter, Lavignac, Lavignac, Lavignac, Ledoux, Lee, Leich, Leland, Lienqueo, Liu, Lo, Mahn, Matousek, Mattison, Nicholson, Parhamifar, Parhamifar, Pattrick, Peng, Pfeil, Pouckova, Pouckova, Richardson, Romanini, Sasisanker, Saxena, Sedlak, Seyrek, Smith, Tribet, van de Weert, Vottariello, Wang, Wilson, Xia, Yeo, Zhang   +60 more
core   +1 more source

Difference between Mitochondrial RNase P and Nuclear RNase P [Letters to the Editor] [PDF]

, 2001
[Discussion of: Puranam, R. S., and G. Attardi. 2001. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol. Cell. Biol. 21:548-561.
Attardi, Giuseppe, Potuschak, Thomas, Puranam, Ram S., Rossmanith, Walter   +3 more
core  

The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin [PDF]

, 2015
Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC.
Dimude, JU, Foster, HA, Khan, A, Midgley-Smith, SL, Retkute, R, Rudolph, CJ, Saunders, NJ, Stockum, A, Upton, AL   +8 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]

, 2019
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés, Barroso Ceballos, Sonia Inés, García Rubio, María Luisa, Gómez González, Belén, Herrera Moyano, Emilia, Muñoz Sánchez, Sergio   +5 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source