RNase Y Autoregulates Its Synthesis in Bacillus subtilis [PDF]
Microorganisms, 2023 The instability of messenger RNA is crucial to the control of gene expression. In Bacillus subtilis, RNase Y is the major decay-initiating endoribonuclease.
Anna Korobeinikova +3 more
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Dynamic Membrane Localization of RNase Y in
mBio, 2020 Metabolic turnover of mRNA is fundamental to the control of gene expression in all organisms, notably in fast-adapting prokaryotes. In many bacteria, RNase Y initiates global mRNA decay via an endonucleolytic cleavage, as shown in the Gram-positive model
Lina Hamouche +6 more
doaj +7 more sources
Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold [PDF]
Biomolecules, 2022 RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positive bacteria. The N-terminal domain of Bacillus subtilis RNase Y (Nter-BsRNaseY) is thought to interact with various protein partners ...
Nelly Morellet +4 more
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Bacillus subtilis RNase Y activity in vivo analysed by tiling microarrays. [PDF]
PLoS ONE, 2013 RNase Y is a key endoribonuclease affecting global mRNA stability in Bacillus subtilis. Its characterization provided the first evidence that endonucleolytic cleavage plays a major role in the mRNA metabolism of this organism.
Soumaya Laalami +5 more
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Formation of a stable RNase Y-RicT (YaaT) complex requires RicA (YmcA) and RicF (YlbF) [PDF]
mBio, 2023 In Bacillus subtilis, the RicT (YaaT), RicA (YmcA), and RicF (YlbF) proteins, which form a stable ternary complex, are needed together with RNase Y (Rny) to cleave and thereby stabilize several key transcripts encoding enzymes of intermediary metabolism.
Eugenie Dubnau +2 more
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Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex in Bacillus subtilis. [PDF]
Proc Natl Acad Sci U S A, 2018 Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery A +3 more
europepmc +7 more sources
Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus. [PDF]
PLoS Genetics, 2023 Cellular processes require precise and specific gene regulation, in which continuous mRNA degradation is a major element. The mRNA degradation mechanisms should be able to degrade a wide range of different RNA substrates with high efficiency, but should ...
Alexandre Le Scornet +14 more
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RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori [PDF]
iScienceSummary: Ribonucleases are involved in several biological processes, including the turnover of structural and messenger RNAs and the specific processing of the cellular transcriptome. Here, we characterized the RNase Y from Helicobacter pylori.
Federico D’Agostino +5 more
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An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y [PDF]
Nature Communications, 2020 Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia +6 more
doaj +9 more sources
Genome‐wide screening of potential RNase Y‐processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131 [PDF]
MicrobiologyOpen, 2019 RNase Y is a major endoribonuclease in Group A streptococcus (GAS) and other Gram‐positive bacteria. Our previous study showed that RNase Y was involved in mRNA degradation and processing in GAS.
Zhiyun Chen +4 more
doaj +5 more sources