RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori [PDF]
iScienceSummary: Ribonucleases are involved in several biological processes, including the turnover of structural and messenger RNAs and the specific processing of the cellular transcriptome. Here, we characterized the RNase Y from Helicobacter pylori.
Federico D’Agostino +5 more
doaj +4 more sources
Genome‐wide screening of potential RNase Y‐processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131 [PDF]
MicrobiologyOpen, 2019 RNase Y is a major endoribonuclease in Group A streptococcus (GAS) and other Gram‐positive bacteria. Our previous study showed that RNase Y was involved in mRNA degradation and processing in GAS.
Zhiyun Chen +4 more
doaj +3 more sources
Escherichia coli RNase E can efficiently replace RNase Y in Bacillus subtilis. [PDF]
Nucleic Acids Res, 2021 International audienceAbstract RNase Y and RNase E are disparate endoribonucleases that govern global mRNA turnover/processing in the two evolutionary distant bacteria Bacillus subtilis and Escherichia coli, respectively.
Laalami S +4 more
europepmc +2 more sources
RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B. [PDF]
RNA Biol, 2018 Endoribonuclease Y (RNase Y) is a crucial regulator of virulence in Gram-positive bacteria. In the human pathogen Streptococcus pyogenes, RNase Y is required for the expression of the major secreted virulence factor streptococcal pyrogenic exotoxin B ...
Broglia L +5 more
europepmc +2 more sources
Formation of a stable RNase Y-RicT (YaaT) complex requires RicA (YmcA) and RicF (YlbF) [PDF]
mBio, 2023 In Bacillus subtilis, the RicT (YaaT), RicA (YmcA), and RicF (YlbF) proteins, which form a stable ternary complex, are needed together with RNase Y (Rny) to cleave and thereby stabilize several key transcripts encoding enzymes of intermediary metabolism.
Eugenie Dubnau +2 more
doaj +2 more sources
An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y [PDF]
Nature Communications, 2020 Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia +6 more
doaj +2 more sources
Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus. [PDF]
PLoS GeneticsCellular processes require precise and specific gene regulation, in which continuous mRNA degradation is a major element. The mRNA degradation mechanisms should be able to degrade a wide range of different RNA substrates with high efficiency, but should ...
Alexandre Le Scornet +14 more
doaj +2 more sources
Stress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex [PDF]
Nature CommunicationsLimiting ribosome synthesis and activity is crucial for adaptation to stresses, such as heat or nutrient starvation. In Bacillus subtilis, this can be achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx ...
Fabián A. Cornejo +12 more
doaj +2 more sources
Correction: Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation. [PDF]
PLoS Genetics, 2016 [This corrects the article DOI: 10.1371/journal.pgen.1005577.].
Vanessa Khemici +3 more
doaj +2 more sources
Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex in Bacillus subtilis. [PDF]
Proc Natl Acad Sci U S A, 2018 Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery A +3 more
europepmc +2 more sources