Results 241 to 250 of about 93,670 (312)

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Genomic Signatures of Selection Are Enriched in Differentially Expressed Genes in Sticklebacks Adapting to Contrasting Environments. [PDF]

Genome Biol Evol
Kwakye A, Dzikowski N, Wund MA, Veeramah KR.   +3 more
europepmc   +1 more source

PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx‐Lineage Cells Accelerates Structural and Functional Recovery

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
PIEZO1 supports adaptive matrix remodeling during tendon homeostasis but has a distinct role following injury. ScxCre‐driven Piezo1 depletion reduced Scx+ cell recruitment/accumulation within the healing defect of the patellar tendon and was associated with accelerated collagen remodeling and improved mechanical recovery.
Nicole A. Chittim, Maja Wolleb, Maya Ben‐Yehuda Greenwald, Maja Bollhalder, Jess G. Snedeker   +4 more
wiley   +1 more source

The hidden sources of spurious fusion transcripts in plants. [PDF]

Genome Biol
Zhu XT, Lu X, Zhang Z, Tang Q, Liu M, Xia F, Zhang X, Pablo SJ, Zhou R, Li H, Ouyang Y, Chen LL.   +11 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Decreased Endothelial Cell Retinoic Acid Signaling Accelerates Progression of Single Ventricle Pulmonary Vascular Malformations. [PDF]

JACC Basic Transl Sci
Rousseau H, Wan T, Nguyen N, Andrae JW, Tschannen M, Mathison AJ, Jin V, Groh O, Zhou X, Meadows SM, Ramchandran R, Shmarakov I, Pan AY, Spearman AD.   +13 more
europepmc   +1 more source

Unraveling a Diagnostic Enigma: A TECPR2 Case Solved Through Multi‐Omic Genomics

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2338-2344, October 2026.
ABSTRACT TECPR2 is a key regulator of autophagy, encoded by the TECPR2 gene. Pathogenic variants in this gene have been linked to a rare hereditary sensory and autonomic neuropathy with intellectual disability (HSAN9). We report a teenage female with a syndromic intellectual disability disorder associated with neuromuscular abnormalities.
Teresa Zhao, Andrew P. Fennell, Tanavi Sharma, Katrina M. Bell, Monique Dunstan, Sebastian Lunke, Meagan J. McGrath, Catriona McLean, Isabella Pfundt, Undiagnosed Diseases Network (UDN‐Aus), Alison Yeung, Anna Hackett, Anne Baxter, Ansley Morrish, Ashil Davawala, Azure Hermes, Ben Kamien, Ben Lundie, Carolyn Ellaway, Carolyn Shalhoub, Cas Simons, Cassandra Gray, Cathryn Poulton, Chloe Cunningham, Chris Barnett, Chris Richmond, Christopher Richards, Daniel MacArthur, Daniel Pavlic, Daniella Hock, Daniz Kooshavar, David Amor, David Mowat, Edward Formaini, Elaine Zhang, Ella Wilkins, Ella Zurita, Ellenore Martin, Elly Lynch, Emma Krzesinski, Emma Palmer, Esther Pierini, Evanthia O. Madelli, Francisco Santos Gonzalez, Gareth Baynam, Gunjan Garg, Hamish Scott, Hannah Thomson, Himanshu Goel, Ilias Goranitis, Ira Deveson, Isabella Pfundt, Jacqui Russell, Janine Smith, Jason Pinner, Julia Broadbent, Julie McGaughran, Karin Kassahn, Katherine Lewis, Kaustuv Bhattacharya, Kirsten Boggs, Kirsty West, Kristi Jones, Laura Wedd, Lauren Dreyer, Leah Frajman, Leanne Baxter, Lilian Downie, Lily Loughman, Lisa Bristowe, Lisa Ewans, Louise Cilento, Lucy Kevin, Lyndal Douglas, Madeleine Harris, Maie Walsh, Manisha Chauhan, Margit Shah, Martin Delatycki, Mathew Wallis, Matthew Hunter, Megan Ball, Megan Higgins, Meutia Kumaheri, Michael Fahey, Mike Field, Mohammadreza Hajjari, Natalie Stewart, Natalie Tan, Natasha Brown, Nicole Van Bergen, Noelia Nunez‐Martinez, Oliver Heath, Rachel Austin, Rani Sachdev, Rebecca Macintosh, Rebecca Vink, Rocio Rius, Ruvi Samarasekera, Ryan Pysar, Sandra Cooper, Sarah Casauria, Sarah Collinson, Sarah Jelenich, Sarah Josephi‐Taylor, Sarah Sandaradura, Sean Massey, Shannon Leblanc, Shuxiang Goh, Simon Bodek, Simon Sadedin, Simran Kaur, Smitha Kumble, Sue White, Suzanne Sallevelt, Tegan Stait, Tiffany Boughtwood, Tim Sikora, Timo Lassmann, Tiong Tan, Tracy Dudding, David R. Thorburn, David A. Stroud, John Christodoulou   +123 more
wiley   +1 more source

Longstanding Transcriptional Activation of APOA1 and PON1 in Human Hepatocytes by CRISPR/dCas9 Technology: Transcriptomic Profile and Crosstalk with Endothelial Cells. [PDF]

Int J Mol Sci
Haratau JIC, Niculescu LS, Barbalata T, Sanda GM, Fuior EV, Sasson S, Sima AV, Stancu CS, Toma L.   +8 more
europepmc   +1 more source

Proteomic dysregulation associated with cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain proteomics from Religious Orders Study
Sang‐Won Han, Young Ho Park, Jung‐Min Pyun, Paula J. Bice, David A. Bennett, Shahram Oveisgharan, Andrew J. Saykin, SangYun Kim, Kwangsik Nho   +8 more
wiley   +1 more source

Cellular Neighborhoods Govern Antitumor T-cell Infiltration Following Anti-CTLA-4 in Melanoma with Primary Resistance to Anti-PD-1. [PDF]

Cancer Discov
Campbell KM, Chen DG, Bustami ZE, Naser Al Deen N, Medina E, Gonzalez CR, Maxey J, Thompson MA, Samorodnitsky S, Kuklinski LF, Perez Garcilazo I, Baselga-Carretero I, Vega-Crespo A, Chen JM, Elumalai R, Visitacion M, Schiemann R, Padron L, Chang C, Zelin AE, Chelluri SS, Boffo S, Kendra KL, Chmielowski B, Truong TG, Khushalani NI, Collichio F, Ikeguchi AP, Victor AI, Margolin KA, Johnson DB, Chen Y, Sosman JA, Patel SP, Hu-Lieskovan S, Moon J, Wells DK, Spencer CN, Bellasea S, Vanderwalde AM, Wu MC, Scumpia PO, Ribas A.   +42 more
europepmc   +1 more source