Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus: development, topography, opsin expression and spectral tuning. [PDF]
PLoS ONE, 2013 A quantitative analysis of photoreceptor properties was performed in the retina of the nocturnal deer mouse, Peromyscus maniculatus, using pigmented (wildtype) and albino animals.
Patrick Arbogast +2 more
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BMC Genomics, 2003 Background The vertebrate opsins are proteins which utilise a retinaldehyde chromophore in their photosensory or photoisomerase roles in the visual/irradiance detection cycle.
Foster Russell G +2 more
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Visual responses in mice lacking critical components of all known retinal phototransduction cascades. [PDF]
PLoS ONE, 2010 The mammalian visual system relies upon light detection by outer-retinal rod/cone photoreceptors and melanopsin-expressing retinal ganglion cells. Gnat1(-/-);Cnga3(-/-);Opn4(-/-) mice lack critical elements of each of these photoreceptive mechanisms via ...
Annette E Allen +4 more
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Palmitoylation stabilizes unliganded rod opsin [PDF]
Proceedings of the National Academy of Sciences, 2010 S-palmitoylation is a conserved feature in many G protein–coupled receptors (GPCRs) involved in a broad array of signaling processes. The prototypical GPCR, rhodopsin, is S-palmitoylated on two adjacent C-terminal Cys residues at its cytoplasmic surface.
Akiko Maeda +6 more
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Genomic organization of duplicated short wave-sensitive and long wave-sensitive opsin genes in the green swordtail,
BMC Evolutionary Biology, 2010 Background Long wave-sensitive (LWS) opsin genes have undergone multiple lineage-specific duplication events throughout the evolution of teleost fishes. LWS repertoire expansions in live-bearing fishes (family Poeciliidae) have equipped multiple species ...
Davidson William S +4 more
doaj +3 more sources
BiP prevents rod opsin aggregation
Molecular Biology of the Cell, 2012 Mutations in rod opsin—the light-sensitive protein of rod cells—cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin.
Dimitra Athanasiou +7 more
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Vision using multiple distinct rod opsins in deep-sea fishes [PDF]
Science, 2018 AbstractVertebrate vision is accomplished through a set of light-sensitive photopigments, which are located in the photoreceptors of the retina and consist of a visual opsin protein bound to a chromophore. In dim-light, vertebrates generally rely upon a single rod opsin (RH1) for obtaining visual information.
Zuzana Musilová +14 more
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Biosynthesis and vectorial transport of opsin on vesicles in retinal rod photoreceptors. [PDF]
Journal of Histochemistry & Cytochemistry, 1986 Retinal rod photoreceptor cells absorb light at one end and establish synaptic contacts on the other. Light sensitivity is conferred by a set of membrane and cytosol proteins that are gathered at one end of the cell to form a specialized organelle, the rod outer segment (ROS).
David S. Papermaster +3 more
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Occupancy of the Chromophore Binding Site of Opsin Activates Visual Transduction in Rod Photoreceptors [PDF]
The Journal of General Physiology, 1999 The retinal analogue β-ionone was used to investigate possible physiological effects of the noncovalent interaction between rod opsin and its chromophore 11-cis retinal. Isolated salamander rod photoreceptors were exposed to bright light that bleached a significant fraction of their pigment, were allowed to recover to a steady state, and then were ...
Vladimir J. Kefalov +2 more
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Opsin Kinase Activities Characterize Light Responses of Rod and Cone Photoreceptors
Seibutsu Butsuri, 2013 Tomoya Shiraki, Yoshitaka Fukada
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