Results 91 to 100 of about 4,969,940 (302)

The Effect of Role Conflict, Role Ambiguity, and Role Overload in Burnout Government Internal Supervisors with Tri Hita Karana Culture as Moderation [PDF]

open access: yes, 2019
This study aims to obtain empirical evidence of Tri Hita Karana\u27s cultural abilities in moderating the effect of role conflict, role ambiguity, and the role overload in burnout experienced by the Government Internal Supervisory Apparatus (APIP) at the
Pratiwi, I. Y. (Ida)   +3 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conflict in Organizations: The Role of Routine

open access: yesSSRN Electronic Journal, 2010
The goal of this conceptual paper is to apply the insights of recent routine research in the area of conflict and conflict management. As a result, the authors identify four different types of conflict sources that are rooted in routines and the specific difficulties connected with their change: the repetitive character of routine, disagreement over ...
Kesting, Peter   +2 more
openaire   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Konflik peran kerja-keluarga pada ibu bekerja terhadap perilaku obesogenis anak sekolah dasar

open access: yesJurnal Gizi Klinik Indonesia, 2014
Background: Childbearing pattern of parents greatly affects the healthy lifestyle of children including behaviors preventing children from obesity. Working mothers with a dual role at work and the family face challenges in doing so.
Almira Sitasari   +2 more
doaj   +1 more source

The Manager’s Dilemma: Role Conflict in Marketing [PDF]

open access: yes
Norris Brisco, Melvin Copeland, Henry Erdman, Benjamin Hibbard, George Hotchkiss, Leverett Lyon, Stanley Resor, Clarence Saunders, Harry Tosdal, Roland Vaile: Who are these people?
JS Armstrong
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Decentralization and Ethnic Conflict: The Role of Empowerment [PDF]

open access: yes
Decentralization is increasing in all parts of the world. Assessing the efficiency of decentralization as a means to mitigate ethnic conflict is then of primarily importance.
Tranchant, Jean-Pierre
core   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Role stress and work engagement as antecedents of job satisfaction in Spanish workers

open access: yesJournal of Industrial Engineering and Management, 2014
Purpose: According to the Job Demands-Resources (JDR) model, engagement and job satisfaction may be produce by two types of working conditions: job demands (i.e. role stress) and job resources (i.e. self-efficacy).
Alejandro Orgambídez-Ramos   +2 more
doaj   +1 more source

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