Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Role of miRNAs in Legume Crops in Response to Biotic and Abiotic Stress
, 2017 Legumes are special group of nitrogen-fixing plants that are an essential component of cropping system and important source of food/feed for human/animal consumption.
Sandeep Kumar +6 more
core +1 more source
The Impact of Interactive Control in Budget Management on Innovation Performance of Enterprises: From the Perspective of Manager Role Stress. [PDF]
Int J Environ Res Public Health, 2023 Zeng X, Zhang N, Chen L, Zhang W.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Impact role stress on turnover intentions of Pakistan's healthcare workers: Mediating and moderating role of organizational cynicism and self-efficacy. [PDF]
PLoS One, 2022 Nazir T +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
ROLE STRESS AND ITS OUTCOMES: EVIDENCE FROM HOTEL INDUSTRY OF PAKISTAN [PDF]
Journal of Applied Structural Equation Modeling, 2018 Asif Nawaz, Kamran Yousaf Sandhu
doaj +1 more source
The Moderating Effect of Organizational Identification on the Relationship Between Organizational Role Stress and Job Satisfaction. [PDF]
Front Psychol, 2022 Eriş A, Kökalan Ö.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
An Exploratory Study of Gender Role Stress and Psychological Distress of Women in Kosovo. [PDF]
Womens Health (Lond), 2022 Kelmendi K, Jemini-Gashi L.
europepmc +1 more source