Results 61 to 70 of about 1,603,483 (285)
BMC PsychiatryBackground The implementation of peer-led programs provided by individuals with lived experience of mental disorders has been increasingly acknowledged as a key component in improving the quality of mental health services.
Maren Kjeldstad +4 more
doaj +1 more source
Redox Report, 2020 Objectives: Skeletal muscle adaptation to physical activity is dependent on various factors. Important signaling mediators are reactive oxygen species (ROS).
Angelika Schmitt +5 more
doaj +1 more source
Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells
Antioxidants, 2020 Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese +4 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Nox2 redox signaling maintains essential cell populations in the brain. [PDF]
, 2011 Reactive oxygen species (ROS) are conventionally classified as toxic consequences of aerobic life, and the brain is particularly susceptible to ROS-induced oxidative stress and damage owing to its high energy and oxygen demands.
Chang, Christopher J +4 more
core
Testing weighted splitting schemes on a one-column transport-chemistry model [PDF]
, 2004 In many transport-chemistry models, a huge system of ODE’s of the advection-diffusion-reaction type has to be integrated in time. Typically, this is done with the help of operator splitting.
Botchev, M.A., Farago, I., Havasi, A.
core +4 more sources
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Biologia Plantarum, 2020 In plants, auxin/indoleacetic acid (Aux/IAA) proteins are transcriptional regulators, which regulate developmental process and responses to phytohormones and stress treatments.
G. LI +9 more
doaj +1 more source
Fire Risk Model for Fires in Ro-Ro Ship Ro-Ro Spaces
Journal of Risk Analysis and Crisis ResponseIn recent years, fire accidents on Ro-Ro ships have led to numerous fatalities and significant economic losses. The response of the crew and the ship's protection systems are crucial in managing these incidents and mitigating their consequences. To assess fire safety improvements, this study has focused on developing and quantifying a risk model that ...
Dahlbom, Sixten +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source