Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells
Antioxidants, 2020 Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese +4 more
doaj +1 more source
Fire Risk Model for Fires in Ro-Ro Ship Ro-Ro Spaces
Journal of Risk Analysis and Crisis ResponseIn recent years, fire accidents on Ro-Ro ships have led to numerous fatalities and significant economic losses. The response of the crew and the ship's protection systems are crucial in managing these incidents and mitigating their consequences. To assess fire safety improvements, this study has focused on developing and quantifying a risk model that ...
Dahlbom, Sixten +4 more
openaire +3 more sources
Average household incomes for UK pensioners are reducing each year due to harmful government reforms and the Bank of England’s monetary policies [PDF]
, 2012 Ros Altmann argues for supporting pensioners who have been negatively impacted by monetary and fiscal policy since 2008. She highlights the distributional inequities of the Bank of England’s policies in dealing with the economy and calls for more ...
Altmann, Ros
core
Menadione-induced oxidative stress re-shapes the oxylipin profile of Aspergillus flavus and its lifestyle [PDF]
, 2015 Aspergillus flavus is an efficient producer of mycotoxins, particularly aflatoxin B1, probably the most hepatocarcinogenic naturally-occurring compound.
Cigliano, Riccardo Aiese +9 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Boundary regularity, Pohozaev identities, and nonexistence results
, 2017 In this expository paper we survey some recent results on Dirichlet problems of the form $Lu=f(x,u)$ in $\Omega$, $u\equiv0$ in $\mathbb R^n\backslash\Omega$. We first discuss in detail the boundary regularity of solutions, stating the main known results
Ros-Oton, Xavier
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Biologia Plantarum, 2020 In plants, auxin/indoleacetic acid (Aux/IAA) proteins are transcriptional regulators, which regulate developmental process and responses to phytohormones and stress treatments.
G. LI +9 more
doaj +1 more source
Человек как мера. Беседа с Матсом Розенгреном о контексте возникновения доксологии [PDF]
, 2018 A subject of a conversation is the social context for the emergence of a doxology as a project of the naturalised theory of knowledge. The Swedish philosopher Mats Rosengren developed the doxology.
Nydahl, Mikael, Rosengren, Mats
core
Testing weighted splitting schemes on a one-column transport-chemistry model [PDF]
, 2004 In many transport-chemistry models, a huge system of ODE’s of the advection-diffusion-reaction type has to be integrated in time. Typically, this is done with the help of operator splitting.
Botchev, M.A., Farago, I., Havasi, A.
core +4 more sources