Results 101 to 110 of about 29,549 (204)

Peer Methods for the Solution of Large-Scale Differential Matrix Equations

, 2018
We consider the application of implicit and linearly implicit (Rosenbrock-type) peer methods to matrix-valued ordinary differential equations. In particular the differential Riccati equation (DRE) is investigated.
Benner, Peter, Lang, Norman
core  

VCL::ROS1: A Novel ROS1 Oncogenic Fusion Detected on Next Generation Sequencing

Clinical Pathology
Advanced Non-Small Cell Lung Carcinoma (NSCLC) patients with ROS1 gene rearrangement have shown significant therapeutic responses to tyrosine kinase inhibitors approved by the US Food and Drug Administration, with approximately 40 fusion partners documented in the existing literature.
Anurag Mehta, Himanshi Diwan, Shrinidhi Nathany, Ullas Batra, Manoj Gupta, Manoj Kumar Panigrahi, Dushyant Kumar, Sakshi Mattoo, Aayushi Singh   +8 more
openaire   +2 more sources

Clinicopathological significance and diagnostic approach of ROS1 rearrangement in non-small cell lung cancer: a meta-analysis: ROS1 in non-small cell lung cancer

The International Journal of Biological Markers, 2018
Purpose: The aim of this study was to investigate the rate of ROS1 rearrangement and concordance between ROS1 immunohistochemistry (IHC) and molecular tests in non-small cell lung cancer (NSCLC).
Jungho Yang, Jung-Soo Pyo, Guhyun Kang
doaj   +1 more source

A Real‐World Study: Therapeutic Outcomes of ROS1‐Positive Advanced NSCLC

Thoracic Cancer
Background ROS1 gene rearrangement is an important target for NSCLC treatment. There is not yet sufficient real‐world data on ROS1 diagnostic methods, treatment selection, and clinical outcomes in the Chinese population.
Hanqi Yuan, Zihua Zou, Xuezhi Hao, Yan Li, Junling Li, Jianming Ying, Puyuan Xing   +6 more
doaj   +1 more source

Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain

Scientific Reports
The ROS1 receptor tyrosine kinase (RTK) possesses the largest extracellular amino-terminal domain (ECD) among the human RTK family, yet the mechanisms regulating its activation are not fully understood. While chimeric ROS1 fusion proteins, resulting from
Kristen Jones, Clare Keddy, Chelsea Jenkins, Katelyn Nicholson, Ujwal Shinde, Monika A. Davare   +5 more
doaj   +1 more source

Pyros : ROS1 avec une perspective Python. Retour d’expérience interfaçage ROS1 / Web.

ROSCon France, 2019

openaire   +1 more source

Going beyond EGFR [PDF]

, 2017
a substantial proportion of non-small-cell lung cancer (NSCLC), and adenocarcinoma in particular, depends on a so-called ‘driver mutation' for their malignant phenotype.
Peters, S., Zimmermann, S.
core  

Lung adenocarcinoma patients with ROS1-rearranged tumors by sex and smoking intensity

Heliyon
Background: ROS1 rearrangements (ROS1+) define a distinct molecular subset of lung adenocarcinomas. ROS1 + tumors are known to occur more in never-smokers, but the frequency and outcome of ROS1 positivity by sex and smoking intensity are not clearly ...
Yanmei Peng, Vinicius Ernani, Dan Liu, Qian Guo, Markay Hopps, Joseph C. Cappelleri, Ruchi Gupta, Mariza de Andrade, Jun Chen, Eunhee S. Yi, Ping Yang   +10 more
doaj   +1 more source

Current treatment and novel insights regarding ROS1‐targeted therapy in malignant tumors

Cancer Medicine
Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the tyrosine kinase/insulin receptor family. ROS1 facilitates the progression of various malignancies via self‐mutations or rearrangements.
Shizhe Li, He Zhang, Ting Chen, Xiaowen Zhang, Guanning Shang   +4 more
doaj   +1 more source

Prevalence of ROS1 fusion in Chinese patients with non‐small cell lung cancer

Thoracic Cancer, 2019
Background The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non‐small cell lung cancer (NSCLC).
Qing Zhang, Chunyan Wu, Wei Ding, Zhihong Zhang, Xueshan Qiu, Dianbin Mu, Haiqing Zhang, Yanfeng Xi, Jianhua Zhou, Liheng Ma, Shijun Fu, Min Gao, Bo Wang, Juan Deng, Dongmei Lin, Jie Zhang   +15 more
doaj   +1 more source