MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
Thoracic Cancer, 2022 Background ROS1 tyrosine kinase inhibitors (TKIs) have demonstrated significant clinical benefit for ROS1+ NSCLC patients. However, TKI resistance inevitably develops through ROS1 kinase domain (KD) modification or another kinase driving bypass signaling.
Logan C. Tyler +13 more
doaj +1 more source
Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy
Current Oncology, 2022 Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK)/receptor tyrosine kinase inhibitor (ROS1), demonstrated efficacy in ROS1 positive (ROS1+) non-small cell lung cancer (NSCLC), although approval is currently limited to the treatment of ALK ...
Balázs Jóri +6 more
doaj +1 more source
Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach:A multi-institutional research study [PDF]
, 2018 Contains fulltext : 195300.pdf (publisher's version ) (Open ...
A Marchetti +55 more
core +5 more sources
Advanced Science, EarlyView.Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen +14 more
wiley +1 more source
Improving approximate matrix factorizations for implicit time integration in air pollution modelling [PDF]
, 2000 For a long time operator splitting was the only computationally feasible way of implicit time integration in large scale Air Pollution Models. A recently proposed attractive alternative is Rosenbrock schemes combined with Approximate Matrix Factorization
Botchev, M.A., Verwer, J.G.
core +3 more sources
HLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells [PDF]
, 2019 Leukemia-associated antigens (LAAs) and HLA-I epitopes published previously have shown promise in inducing leukemia-specific T cell responses. However, the clinical responses are limited, and clinical effectiveness is yet to be achieved.
Coutre, Philipp le +3 more
core +1 more source
Analysis of SWI Complex Subunits in 69 Cases of TTF‐1 Negative Non‐Small Cell Lung Carcinoma
Diagnostic Cytopathology, EarlyView.ABSTRACT Non‐small cell lung carcinomas, not otherwise specified (NSCLC‐NOS) with a specific signature including high‐grade hepatoid/clear cell morphology, negative lung panel mutational analysis, negative TTF‐1/Napsin A staining can be reported as a morphologic variant of an aggressive carcinoma with loss of one of the subunits of the SWI/SNF ...
Ramin Zargham +2 more
wiley +1 more source
Thoracic Cancer, 2021 C‐ros oncogene 1 receptor tyrosine kinase (ROS1) rearrangement has been detected in patients with advanced non‐small cell lung cancer (NSCLC). Although ROS1 tyrosine kinase inhibitors (TKIs) provide a survival benefit for patients with ROS1‐rearranged ...
Chi‐Hao Wu +4 more
doaj +1 more source
Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication [PDF]
, 2013 Replication Protein A (RPA) is a heterotrimeric protein complex that binds single-stranded DNA. In plants, multiple genes encode the three RPA subunits (RPA1, RPA2 and RPA3), including five RPA1-like genes in Arabidopsis.
Aklilu, Behailu B. +2 more
core +5 more sources
Correlation of ROS1 Immunohistochemistry With ROS1 Fusion Status Determined by Fluorescence In Situ Hybridization [PDF]
Archives of Pathology & Laboratory Medicine, 2019 Context.— The ability to determine ROS1 status has become mandatory for patients with lung adenocarcinoma, as many global authorities have approved crizotinib for patients with ROS1-positive lung adenocarcinoma. Objective.— To present analytical ...
Huang, Richard +27 more
openaire +4 more sources