Results 1 to 10 of about 1,335 (123)

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection [PDF]

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
doaj   +6 more sources

Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
A major concern of xenotransplantation is that donor organs may be a source of pathogens. One pathogen in particular, porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV), is thought to result in donor organ failure in an immunosuppressed state ...
Susan K. Schommer, Susan K. Schommer, Melissa S. Samuel, Melissa S. Samuel, Kristin M. Whitworth, Kristin M. Whitworth, Addison K. Byrne, Kevin D. Wells, Kevin D. Wells, Randall S. Prather, Randall S. Prather   +10 more
doaj   +6 more sources

Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation [PDF]

Virology Journal, 2023
Background Porcine cytomegalovirus (PCMV) is a porcine roseolovirus (PCMV/PRV) which is widely distributed in pigs. Transmission of PCMV/PRV in preclinical xenotransplantations was shown to significantly reduce the survival time of the pig transplants in
Sabrina Hansen, Konrad Fischer, Ludwig Krabben, Alexander Rinke Carrapeiro, Bernhard Klinger, Angelika Schnieke, Benedikt Kaufer, Joachim Denner   +7 more
doaj   +8 more sources

Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
To address the shortage of human tissues and organs for treating organ failure, xenotransplantation is progressing toward clinical application. Pigs have been chosen as donor species for various reasons, and extensive genetic modifications are being implemented to prevent xenotransplant rejection. However, xenotransplantation may be associated with the
Joachim Denner
doaj   +5 more sources

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense [PDF]

Viruses
Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation.
Hina Jhelum, Reinhold Schäfer, Benedikt B. Kaufer, Joachim Denner   +3 more
doaj   +6 more sources

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7 [PDF]

Frontiers in Immunology, 2022
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins.
Grant C. Weaver, Grant C. Weaver, Richa Arya, Christine L. Schneider, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +7 more
doaj   +5 more sources

Corrigendum: Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7 [PDF]

Frontiers in Immunology, 2022
Grant C. Weaver, Grant C. Weaver, Richa Arya, Christine L. Schneider, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +7 more
doaj   +5 more sources

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains [PDF]

Molecular Neurodegeneration, 2022
Background The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7, and AD.
Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama, David M. Holtzman   +12 more
doaj   +5 more sources

Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]

Methods and Protocols
Xenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum, Benedikt B. Kaufer, Joachim Denner   +2 more
doaj   +2 more sources

HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses [PDF]

iScience
Summary: Human herpesvirus 6B (HHV-6B) belongs to the genus Roseolovirus of the betaherpesvirus subfamily, causing exanthema subitum and encephalitis.
Mansaku Hirai, Khoir Amaliin, Jing Rin Huang, Salma Aktar, Yasuko Mori, Jun Arii   +5 more
doaj   +2 more sources