Results 11 to 20 of about 1,342 (122)

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?

Xenotransplantation, 2022
AbstractThe potential for a donor‐derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV/PRV ...
, Joachim Denner
exaly   +4 more sources

Past, present, and future perspectives on the diagnosis of Roseolovirus infections [PDF]

Current Opinion in Virology, 2014
Diagnosis of Roseolovirus infections mandates careful selection of patients, samples, and testing methods. We review advances in the field and highlight research priorities. Quantitative (q)PCR can accurately identify and distinguish between human herpesvirus 6 (HHV-6) species A and B.
Joshua Hill, Keith Jérôme, Ruth Hall Sedlak   +2 more
exaly   +3 more sources

Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]

Methods and Protocols
Xenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum, Benedikt B. Kaufer, Joachim Denner   +2 more
doaj   +2 more sources

Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany. [PDF]

Arch Virol, 2023
Abstract Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs. PCMV/PRV is important in xenotransplantation, because in preclinical trials in which pig organs were transplanted into non-human primates, transmission of PCMV/PRV was ...
Hansen S, Menandro ML, Franzo G, Krabben L, Marino SF, Kaufer B, Denner J.   +6 more
europepmc   +3 more sources

HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses [PDF]

iScience
Summary: Human herpesvirus 6B (HHV-6B) belongs to the genus Roseolovirus of the betaherpesvirus subfamily, causing exanthema subitum and encephalitis.
Mansaku Hirai, Khoir Amaliin, Jing Rin Huang, Salma Aktar, Yasuko Mori, Jun Arii   +5 more
doaj   +2 more sources

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]

Xenotransplantation
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc   +2 more sources

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7

Frontiers in Immunology, 2022
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins.
Grant C. Weaver, Grant C. Weaver, Richa Arya, Christine L. Schneider, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +7 more
doaj   +4 more sources

Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]

J Med Virol
ABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS, Gonçalves JP, Pereira NS, Bonfim FFO, Martinelli KG, Amarante MK, Yamada-Ogatta SF, Franco LC, Galhardi LCF, de Paula VS.   +9 more
europepmc   +2 more sources

Application of Methods Detecting Xenotransplantation-Relevant Viruses for Screening German Slaughterhouse Pigs [PDF]

Viruses
Detection methods have been developed to prevent transmission of zoonotic or xenozoonotic porcine viruses after transplantation of pig organs or cells to the recipient (xenotransplantation).
Hina Jhelum, Benedikt Kaufer, Joachim Denner   +2 more
doaj   +2 more sources

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju [PDF]

Proceedings of the Latvian Academy of Sciences, 2016
Abstract Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses ...
Santa Rasa-Dzelzkaleja, Angelika Krumina, Modra Murovska   +2 more
exaly   +2 more sources