Results 11 to 20 of about 1,950 (144)

Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
To address the shortage of human tissues and organs for treating organ failure, xenotransplantation is progressing toward clinical application. Pigs have been chosen as donor species for various reasons, and extensive genetic modifications are being ...
Joachim Denner
exaly   +8 more sources

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains [PDF]

Molecular Neurodegeneration, 2022
Background The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7, and AD.
Tarin M Bigley, Monica Xiong, Yun Chen
exaly   +8 more sources

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection [PDF]

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
exaly   +6 more sources

Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
A major concern of xenotransplantation is that donor organs may be a source of pathogens. One pathogen in particular, porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV), is thought to result in donor organ failure in an immunosuppressed state ...
Susan K. Schommer, Susan K. Schommer, Melissa S. Samuel, Melissa S. Samuel, Kristin M. Whitworth, Kristin M. Whitworth, Addison K. Byrne, Kevin D. Wells, Kevin D. Wells, Randall S. Prather, Randall S. Prather   +10 more
exaly   +6 more sources

Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation [PDF]

Virology Journal, 2023
Background Porcine cytomegalovirus (PCMV) is a porcine roseolovirus (PCMV/PRV) which is widely distributed in pigs. Transmission of PCMV/PRV in preclinical xenotransplantations was shown to significantly reduce the survival time of the pig transplants in
Sabrina Hansen, Konrad Fischer, Ludwig Krabben, Alexander Rinke Carrapeiro, Bernhard Klinger, Angelika Schnieke, Benedikt Kaufer, Joachim Denner   +7 more
doaj   +8 more sources

Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany [PDF]

Archives of Virology, 2023
Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs.
Stephen F Marino, Joachim Denner
exaly   +7 more sources

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation? [PDF]

Xenotransplantation, 2022
The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation.
Nicolas J Mueller, Joachim Denner
exaly   +8 more sources

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis [PDF]

Journal of Experimental Medicine, 2022
Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity ...
Tarin M Bigley, Liping Yang, Liang-I Kang   +2 more
exaly   +7 more sources

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7

Frontiers in Immunology, 2022
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins.
Amy W Hudson, Christine L Schneider
exaly   +6 more sources

Role of a Porcine Herpesvirus, PCMV/PRV, in Xenotransplantation [PDF]

Transplant International
Xenotransplantation using pig organs may be associated with the transmission of porcine viruses that could cause disease in recipients. A well-known example is the porcine cytomegalovirus, which is actually a porcine roseolovirus, hence abbreviated as ...
Joachim Denner
doaj   +5 more sources