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Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection [PDF]

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Tarin Bigley, Paley Michael A, Robérson Elisha D O   +2 more
exaly   +6 more sources

Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
To address the shortage of human tissues and organs for treating organ failure, xenotransplantation is progressing toward clinical application. Pigs have been chosen as donor species for various reasons, and extensive genetic modifications are being implemented to prevent xenotransplant rejection. However, xenotransplantation may be associated with the
Joachim Denner, Denner Joachim
exaly   +6 more sources

Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]

Frontiers in Veterinary Science
A major concern of xenotransplantation is that donor organs may be a source of pathogens. One pathogen in particular, porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV), is thought to result in donor organ failure in an immunosuppressed state ...
Kristin Whitworth, Randall Prather, Kevin D Wells   +2 more
exaly   +6 more sources

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense [PDF]

Viruses
Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation.
Reinhold Schafer, Benedikt B Kaufer, Joachim Denner   +2 more
exaly   +6 more sources

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains [PDF]

Molecular Neurodegeneration, 2022
Background The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7, and AD.
Swapneel Patel, Tarin Bigley, CARLOS Cruchaga   +2 more
exaly   +5 more sources

Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation [PDF]

Virology Journal, 2023
Background Porcine cytomegalovirus (PCMV) is a porcine roseolovirus (PCMV/PRV) which is widely distributed in pigs. Transmission of PCMV/PRV in preclinical xenotransplantations was shown to significantly reduce the survival time of the pig transplants in
Sabrina Hansen, Konrad Fischer, Ludwig Krabben, Alexander Rinke Carrapeiro, Bernhard Klinger, Angelika Schnieke, Benedikt Kaufer, Joachim Denner   +7 more
doaj   +4 more sources

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis [PDF]

Journal of Experimental Medicine, 2022
Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity long after acute infection.
Liang-I Kang, Tarin Bigley, FRANCISCO Victorino   +2 more
exaly   +4 more sources

Corrigendum: Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7 [PDF]

Frontiers in Immunology, 2022
Grant C. Weaver, Grant C. Weaver, Richa Arya, Christine L. Schneider, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +7 more
doaj   +3 more sources

Is There an Ethical Dilemma in Xenotransplantation? [PDF]

Xenotransplantation
ABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Denner J.
europepmc   +2 more sources

Roseolovirus molecular biology: recent advances [PDF]

Current Opinion in Virology, 2014
Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, and HHV-7) are classified within the roseolovirus genus of the betaherpesvirus subfamily. Most humans likely harbor at least two of these large DNA viruses, and 1% of humans harbor germline chromosomally integrated (ci) HHV-6A or HHV-6B genomes.
Philip Pellett, Laurie T Krug
exaly   +3 more sources