First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs [PDF]
Xenotransplantation, 2023 Joachim Denner
exaly +5 more sources
The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]
BiomedicinesCardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender +23 more
doaj +5 more sources
Potential Infectious Complications in Pig Xenograft Donors and Recipients [PDF]
Transplant InternationalPreclinical and clinical xenotransplantation trials have shown that successful outcomes depend on a number of factors including the prevention of xenozoonoses.
Nicolas J. Mueller, Linda Scobie
doaj +5 more sources
Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]
Frontiers in Immunology, 2022 Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian +7 more
doaj +8 more sources
Corrigendum: Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7 [PDF]
Frontiers in Immunology, 2022 Grant C. Weaver +7 more
doaj +3 more sources
Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense [PDF]
VirusesPorcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation.
Hina Jhelum +3 more
doaj +2 more sources
Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes [PDF]
Viruses, 2017 Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry ...
Joshua G. Tweedy +3 more
doaj +4 more sources
A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion [PDF]
Journal of Virology, 2017 The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Swapneel J Patel +2 more
exaly +3 more sources
Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]
Methods and ProtocolsXenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum +2 more
doaj +2 more sources
HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses [PDF]
iScienceSummary: Human herpesvirus 6B (HHV-6B) belongs to the genus Roseolovirus of the betaherpesvirus subfamily, causing exanthema subitum and encephalitis.
Mansaku Hirai +5 more
doaj +2 more sources